Desmoglein 4 diversity and correlation analysis with coat color in goat

文献类型： 外文期刊

第一作者： E, G. X.

作者： E, G. X.;Zhao, Y. J.;Na, R. S.;Zhao, Z. Q.;Jiang, C. D.;Zhang, J. H.;Chen, L. P.;Qiu, X. Y.;Hu, W.;Huang, Y. F.;Ma, Y. H.;Cao, G. L.;He, J. N.;Arlvd, S.

作者机构：

关键词： Desmoglein 4;Diversity;Goat;Evolution;Correlation analysis

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2016 年 15 卷 1 期

页码：

收录情况： SCI

摘要： Desmoglein 4 (DSG4) has an important role in the development of wool traits in domestic animals. The full-length DSG4 gene, which contains 3918 bp, a complete open-reading-frame, and encodes a 1040-amino acid protein, was amplified from Liaoning cashmere goat. The sequence was compared with that of DSG4 from other animals and the results show that the DSG4 coding region is consistent with interspecies conservation. Thirteen single-nucleotide polymorphisms (SNPs) were identified in a highly variable region of DSG4, and one SNP (M-1, G>T) was significantly correlated with white and black coat color in goat. Haplotype distribution of the highly variable region of DSG4 was assessed in 179 individuals from seven goat breeds to investigate its association with coat color and its differentiation among populations. However, the lack of a signature result indicates DGS4 haplotypes related with the color of goat coat.

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