Gene expression changes in chicken NLRC5 signal pathway associated with in vitro avian leukosis virus subgroup J infection

文献类型: 外文期刊

第一作者: Qiu, L. L.

作者: Qiu, L. L.;Xu, L.;Guo, X. M.;Li, Z. T.;Wan, F.;Chen, G. H.;Chang, G. B.;Liu, X. P.

作者机构:

关键词: Avian leukosis virus;Chicken embryo fibroblast;NLRC5;Signal pathway;Real-time PCR

期刊名称:GENETICS AND MOLECULAR RESEARCH ( 影响因子:0.764; 五年影响因子:0.912 )

ISSN: 1676-5680

年卷期: 2016 年 15 卷 1 期

页码:

收录情况: SCI

摘要: Nucleotide-binding oligomerization domain-like receptors (NLRs) play a key role in the innate immune response as pattern-recognition receptors. However, the role of NLRC5, which is a member of the NLR family, in NF-kappa B activation and MHC-I expression remains debatable. Infection with the J group avian leukosis virus (ALV-J) can result in immunosuppression and a subsequent increase in susceptibility to secondary infection. This results in huge economic losses to the poultry industry worldwide. Using quantitative real-time polymerase chain reaction (qRT-PCR), we investigated the mRNA expression levels of NLRC5 signal pathway-related genes in secondary chicken embryo fibroblasts 7 days after infection with ALV-J. The results indicated that, compared with the control groups, the expression levels of TLR7, MHC-I, and IL-18 increased significantly in the infected groups at 7 days post-infection (d.p.i.). The expression levels of NLRC5 and IL-6 were conspicuously downregulated at 7 d.p.i., but the expression levels of NF-kappa B, STAT1, and STAT3 were not significantly altered. These results suggest that NLRC5 and some genes involved in the NLRC5 pathway play a key role in antiviral immunity, typically the response to ALV-J infection. Moreover, MHC-I expression levels vary between different cell types.

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