Polymorphism of exon 2 of DIO2 gene and its association with seasonal reproduction in sheep

文献类型： 外文期刊

第一作者： He, JianNing

作者： He, JianNing;Huang, DongWei;Di, Ran;Wang, JinXin;Chu, MingXing;Liu, QiuYue;Hu, WenPing;Wang, XiangYu;Pan, ZhangYuan;He, JianNing

作者机构：

关键词： Sheep;seasonal reproduction;DIO2 gene;polymorphism

期刊名称：TURKISH JOURNAL OF VETERINARY & ANIMAL SCIENCES （ 影响因子：0.581； 五年影响因子：0.78 ）

ISSN： 1300-0128

年卷期： 2016 年 40 卷 2 期

页码：

收录情况： SCI

摘要： DIO2 was studied as a candidate gene for reproduction in sheep. Three pairs of primers were designed to detect single nucleotide polymorphisms (SNPs) of exon 2 of DIO2 in nonseasonal and seasonal reproduction breeds. The polymorphisms were detected using SeqMan II and analyzed by PCR-RFLP. The sheep DIO2 gene was cloned and its mutations were detected in five sheep breeds whose reproductive seasonality and litter sizes were different. Association analyses were performed to reveal the relationships between SNPs and reproductive seasonality as well as litter size in sheep. The results showed that a 1041-bp DNA fragment of the sheep DIO2 gene was obtained and a part of the coding sequence of 591 bp encodes 196 amino acids, having high homology with that of other mammals. Moreover, three mutations (G318T, G482C, and C885T) were detected. The test of genotype distribution in five sheep breeds showed that there were significant differences between nonseasonal and seasonal breeds for 318 and 482 loci. However, the associations between the three polymorphisms and sheep seasonal reproduction were not very distinct. Additionally, there was no significant associations between polymorphisms and litter sizes in Small Tail Han sheep. These results may provide the basic theory for further study.

分类号：

  • 相关文献

[1]Analysis on DNA sequence of goat RFRP gene and its possible association with average daily sunshine duration. Huang, D. W.,Di, R.,Wang, J. X.,Chu, M. X.,He, J. N.,Cao, G. L.,Fang, L.,Feng, T.,Li, N..

[2]Polymorphism of Prophet of Pit-1 gene and its relationship with litter size of Small Tail Han sheep. Liu, Qiuyue,Chu, Mingxing,Di, Ran,Feng, Tao,Geng, Caixia,Chen, Hongquan,Jin, Mei,Zhang, Yingjie,Li, Ning. 2015

[3]Association analysis between five microsatellite loci and litter size in small tail han sheep. Chu, MX,Wang, JZ,Wang, AG,Li, N,Fu, JL. 2003

[4]Analysis of polymorphism, structure and function of exon 2 of ovine melatonin receptor 1b gene: a clue as to why it lacks expression in sheep. Xiao, Chao-Ting,Chu, Ming-Xing,Fu, Yan,Fang, Li,Ye, Su-Cheng. 2007

[5]Polymorphism of insulin-like growth factor 1 gene and its association with litter size in Small Tail Han sheep. He, J. N.,Chu, M. X.,Feng, T.,Di, R.,Fang, L.,Huang, D. W.,Tang, Q. Q.,Zhang, B. Y.,Wang, P. Q.,Cao, G. L.,Li, N..

[6]Seasonal variation in population characteristics and management implications for brown rats (Rattus norvegicus) within their native range in Harbin, China. Wang, Da-Wei,Yue, Ling-Fen,Huang, Bao-Huan,Li, Ning,Liu, Xiao-Hui,Cong, Lin,Wang, Yu,Zhang, Jian-Xu.

[7]Protecting Local Breeds of Livestock in NW China. Lang Xia,Wang Cailian,Squires, Victor. 2010

[8]Use of the N-alkanes to Estimate Intake, Apparent Digestibility and Diet Composition in Sheep Grazing on Stipa breviflora Desert Steppe. Hu Hong-lian,Lu De-xun,Gao Min,Liu Yong-zhi,Liu Yong-zhi,Li Ya-kui. 2014

[9]Cloning and characterization of ovine immunoglobulin G Fc receptor II (Fc gamma RII). Liu, Yunchao,Qiao, Songlin,Zhang, Gaiping,Xi, Jun,You, Leiming,Tian, Xiaohui,Li, Qiaomu,Zhang, Lina,Guo, Junqing,Liu, Yunchao,Wang, Aiping. 2010

[10]Progress in biotechnology of small ruminants in China. Zhu, YD,Guo, Y,Ni, HM. 1999

[11]Anaplasma phagocytophilum in sheep and goats in central and southeastern China. Yang, Jifei,Liu, Zhijie,Niu, Qingli,Liu, Junlong,Han, Rong,Guan, Guiquan,Li, Youquan,Liu, Guangyuan,Luo, Jianxun,Yin, Hong,Yin, Hong. 2016

[12]Seroprevalence, Isolation, Genotyping, and Pathogenicity of Toxoplasma gondii Strains from Sheep in China. Yang, YuRong,Feng, YongJie,Lu, YaoYao,Liang, HongDe,Zhang, LongXian,Yao, QiuXia,Zhu, XingQuan,Wang, YingHua. 2017

[13]Molecular detection and genetic characterization of Babesia, Theileria and Anaplasma amongst apparently healthy sheep and goats in the central region of Turkey. Zhou, Mo,Cao, Shinuo,Jirapattharasate, Charoonluk,Moumouni, Paul Franck Adjou,Liu, Mingming,Wang, Guanbo,Iguchi, Aiko,Vudriko, Patrick,Suzuki, Hiroshi,Xuan, Xuenan,Zhou, Mo,Cao, Shinuo,Sevinc, Ferda,Sevinc, Mutlu,Ceylan, Onur,Ekici, Sepil. 2017

[14]Polymorphisms of coding region of BMPR-IB gene and their relationship with litter size in sheep. Chu, Mingxing,Fang, Li,Di, Ran,Cao, Guiling,Feng, Tao,Tang, Qianqian,Ma, Yuehui,Li, Kui,Jia, Lihua,Chen, Hongquan,Zhang, Yingjie,Jin, Mei. 2011

[15]Ovine prion protein genotype frequencies in northwestern China. Zhao, C. -L.,Wu, R.,Liu, L.,Zhang, X. -L.,Wang, C.,Wang, F.,Diao, X. -L.,Guan, H. -W.,Wang, X.,Zhou, L.,Wu, R.,Li, F. -D.. 2012

[16]Genomic resources for a unique, low-virulence Babesia taxon from China. Guan, Guiquan,Li, Youquan,Liu, Zhijie,Luo, Jianxun,Yin, Hong,Guan, Guiquan,Korhonen, Pasi K.,Young, Neil D.,Koehler, Anson V.,Wang, Tao,Gasser, Robin B.. 2016

[17]Biological characterization of sheep kidney-derived mesenchymal stem cells. Ji, Meng,Bai, Chunyu,Fan, Ya'nan,Ma, Caiyun,Li, Xiangchen,Guan, Weijun,Li, Lu. 2016

[18]Genes Expression Related to Intramuscular Fat Deposition in Muscles of Small Tail Han Sheep. Liu, Yan,Ma, Teng,Du, Weihua,Hao, Haisheng,Wang, Dong,Zhao, Xueming,Li, Haijing,Jiang, Qiuling,Zhu, Huabin. 2012

[19]Production and testing of Schistosoma japonicum candidate vaccine antigens in the natural ovine host. Taylor, MG,Huggins, MC,Shi, FH,Lin, JJ,Tian, E,Ye, P,Shen, W,Qian, CG,Lin, BF,Bickle, QD. 1998

[20]Course of infection by Babesia sp BQ1 (Lintan) and B-divergens in sheep depends on the production of IFN gamma and IL10. Moreau, E.,Guan, G.,Yin, H.,Luo, J.. 2010

作者其他论文 更多>>

微信小程序