Recent advances in developing vaccines against Toxoplasma gondii: an update

文献类型： 外文期刊

第一作者： Zhang, Nian-Zhang

作者： Zhang, Nian-Zhang;Wang, Meng;Xu, Ying;Zhu, Xing-Quan;Xu, Ying;Petersen, Eskild

作者机构：

关键词： adjuvant;delivery system;Toxoplasma gondii;toxoplasmosis;vaccines;vaccine candidates

期刊名称：EXPERT REVIEW OF VACCINES （ 影响因子：5.217； 五年影响因子：5.106 ）

ISSN： 1476-0584

年卷期： 2015 年 14 卷 12 期

页码：

收录情况： SCI

摘要： Toxoplasma gondii, a significant public health risk, is able to infect almost all warm-blooded animals including humans, and it results in economic losses in production animals. In the last three years, a large number of vaccination experiments have been performed to control T. gondii infection, with the target of limiting the acute infection and reducing or eliminating tissue cysts in the intermediate hosts. In this paper, we summarize the latest results of the veterinary vaccines against T. gondii infection since 2013. Immunization with live-attenuated whole organisms of non-reverting mutants has been shown to induce remarkably potent immune responses associated with control of acute and chronic toxoplasmosis. The non-cyst-forming mutants are promising new tools for the development of veterinary vaccines against T. gondii infection.

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