Differential and spatial regulation of the prophenoloxidase (proPO) and proPO-activating enzyme in cuticular melanization and innate immunity in Bombyx mori pupae

文献类型: 外文期刊

第一作者: Zou, Feng Ming

作者: Zou, Feng Ming;Lee, Kwang Sik;Kim, Bo Yeon;Jin, Byung Rae;Zou, Feng Ming;Kim, Hong Ja;Gui, Zhong Zheng;Zhang, Guo Zheng;Guo, Xijie

作者机构:

关键词: Bombyx mori;Cuticular melanization;Development;Innate immunity;Prophenoloxidase

期刊名称:JOURNAL OF ASIA-PACIFIC ENTOMOLOGY ( 影响因子:1.303; 五年影响因子:1.427 )

ISSN: 1226-8615

年卷期: 2015 年 18 卷 4 期

页码:

收录情况: SCI

摘要: Insect cuticular melanization is regulated by the prophenoloxidase (proPO)-activating system, which is also involved in the innate immune reaction. Here, we demonstrate how the differentiation of the proPO-activating system is regulated toward a cuticular melanization or innate immunity function in silkworm (Bombyx mori) pupae. Our results indicate that the differential and spatial regulation of key components, such as the proPO-activating enzyme and proPOs, primes the proPO-activating system for either cuticular melanization or innate immunity. This dual strategy for cuticular melanization in development and innate immunity upon infection demonstrates a two-pronged defense mechanism that is mediated by the priming of the proPO system. (C) 2015 Korean Society of Applied Entomology, Taiwan Entomological Society and Malaysian Plant Protection Society. Published by Elsevier B.V. All rights reserved.

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