Dual mode of action of Bt proteins: protoxin efficacy against resistant insects

文献类型： 外文期刊

第一作者： Zhang, Min

作者： Zhang, Min;Wei, Jizhen;Yelich, Alexander;Unnithan, Gopalan C.;Carriere, Yves;Li, Xianchun;Fabrick, Jeffrey A.;Wu, Yidong;Gao, Meijing;Huang, Fangneng;Wei, Jizhen;Zhang, Jie;Bravo, Alejandra;Soberon, Mario

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2015 年 5 卷

页码：

收录情况： SCI

摘要： Transgenic crops that produce Bacillus thuringiensis (Bt) proteins for pest control are grown extensively, but insect adaptation can reduce their effectiveness. Established mode of action models assert that Bt proteins Cry1Ab and Cry1Ac are produced as inactive protoxins that require conversion to a smaller activated form to exert toxicity. However, contrary to this widely accepted paradigm, we report evidence from seven resistant strains of three major crop pests showing that Cry1Ab and Cry1Ac protoxins were generally more potent than the corresponding activated toxins. Moreover, resistance was higher to activated toxins than protoxins in eight of nine cases evaluated in this study. These data and previously reported results support a new model in which protoxins and activated toxins kill insects via different pathways. Recognizing that protoxins can be more potent than activated toxins against resistant insects may help to enhance and sustain the efficacy of transgenic Bt crops.

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