文献类型： 外文期刊
第一作者： Yin, Xiang
作者： Yin, Xiang;Qi, Yan;Wang, Shuyu;Jiang, Hongquan;Feng, Honglin;Ren, Ming;Cui, Shangjin
作者机构：
关键词： Roscovitine;Reproductive toxicity;Male mice
期刊名称：TOXICOLOGY LETTERS （ 影响因子：4.372； 五年影响因子：4.372 ）
ISSN： 0378-4274
年卷期： 2015 年 237 卷 3 期
页码：
收录情况： SCI
摘要： Objective: To explore the adverse effect of roscovitine on reproductive system of male mice. Materials and methods: Male hSOD1(G93A) transgenetic mice received roscovitine 72 nmol/day (d) for 4 weeks (w), with normal control and dimethyl sulfoxide (DMSO)-treated animals served as controls (n = 4). Male C57BL/6 mice were treated with roscovitine at either 72 nmol/d or 144 nmol/d for 4 w or 8 w, and normal control and DMSO treated mice served as controls. Fertility of male mice, sperm quality parameters, histological and related pathological changes of seminiferous tubules associated with roscovitine treatment were evaluated. Results: In male hSOD1(G93A) transgenetic mice treated with 72 nmol/d roscovitine for 4 w and C57BL/6 male mice treated with 72 nmol/d roscovitine for 8 w and 144 nmol/d roscovitine for 4 w and 8 w, sperm counts and sperm motility rates decreased and sperm abnormality rates increased, and damage of seminiferous tubules were detected. Roscovitine treatment induced inhibition of CDK5 activities and decrease of BrdU-positive tubuler cells. Conclusion: These results demonstrated that roscovitine treatment induced interference of male reproductive system and caused impairment of fertilizing ability. Reproductive system of ALS male mice was more susceptible to roscovitine induced impaired fertilizing ability. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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