Syntheses and in vitro Antitumor Activities of N-Acetyl Pyrazolines and Diphenyl Etheryl N-Acetyl Bis-pyrazolines
文献类型: 外文期刊
第一作者: Zhang Yingpeng
作者: Zhang Yingpeng;Tan Wei;Yang Yunshang;Sun Shiqi;Guo Huichen
作者机构: Lanzhou Univ Technol, Sch Petrochem Engn, Lanzhou 730050, Peoples R China;Chinese Acad Agr Sci, Lanzhou Vet Res Inst, Lanzhou 730046, Peoples R China
关键词: N-acetyl pyrazoline;N-acetyl bis-pyrazoline;diphenyl ether;antitumor
期刊名称:CHINESE JOURNAL OF ORGANIC CHEMISTRY ( 2020影响因子:1.652; 五年影响因子:1.2 )
ISSN: 0253-2786
年卷期: 2015 年 35 卷 9 期
收录情况: SCI
摘要: Seven N-acetyl pyrazolines 2a similar to 2g and seven N-acetyl bis-pyrazolines 4a similar to 4g with diphenyl etheryl moiety were synthesized and characterized by H-1 NMR,C-13 NMR, elemental analysis and ESI-MS, and their in vitro antitumor activities on A549, H1299 and MCF-7 were evaluated by 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxypheny1)-2-(4-sulfophenyl-2H-tetraiolium) (MTS) assay. The results showed those compounds exhibited potent antiproliferative effects on cancer cells, among them compound 3,3'-(4,4'-diphenyl ether)-5,5'-bi[1-acetyl-5-(benzo[d][1,3]dioxo-5-yl)-2-pyrazoline] (4e) showed significantly inhibited the growth of all three kinds of cancer cells, the IC50 values of A549, H1299 and MCF-7 were 16.91, 10.09, 10.97 mu mol/L, respectively.
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