Clenbuterol Distribution and Residues in Goat Tissues After the Repeated Administration of a Growth-Promoting Dose

文献类型： 外文期刊

第一作者： Zhao, Zhen

作者： Zhao, Zhen;Yao, Ting;Li, Jun;Li, Junguo;Gu, Xu;Qin, Yuchang;Yang, Xiaowei

作者机构：

期刊名称：JOURNAL OF ANALYTICAL TOXICOLOGY （ 影响因子：3.367； 五年影响因子：3.21 ）

ISSN： 0146-4760

年卷期： 2015 年 39 卷 6 期

页码：

收录情况： SCI

摘要： This study was conducted to investigate the deposition and depletion process of clenbuterol (CL) in goat tissues, plasma and urine after the repeated administration of a growth-promoting dose. The experiment was conducted in 24 goats (21 treated and 3 controls). Treated animals were administered orally in a dose of 16 mu g/kg body mass once daily for 21 consecutive days and randomly sacrificed on days 0.25, 1, 3, 7, 14, 21 and 28 of the withdrawal period. CL in goat tissues was extracted with organic solvents and determined using liquid chromatography tandem mass spectrometry. The depletion rates of tissue differed significantly. The highest concentrations of CL in all tissues are detected on day 0.25 of treatment discontinuation. After administration had been discontinued for 28 days, CL still residues in all tissues, especially, in whole eye, where the concentrations reach 363.29 +/- 31.60 mu g/kg. These findings confirmed that the whole eye, which are rich in pigment, showed a much higher concentration than any other studied tissue during the withdrawal period.

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