Synthesis and Evaluation of Novel N-(4 '-Arylpyrimidin-2 '-yl) Sulfonylurea Derivatives as Potential Antifungal Agents

文献类型： 外文期刊

第一作者： Chen Wei

作者： Chen Wei;Li Yuxin;Wei Wei;Chen Youwei;Li Yonghong;Liu Jingbo;Li Zhengming;Chen Wei;Li Yuxin;Wei Wei;Chen Youwei;Liu Jingbo;Li Zhengming;Shi Yanxia;Li Baoju

作者机构：

关键词： Acetohydroxyacid synthase;Sulfonylurea;Fungicidal activity;Substituted pyrimidine

期刊名称：CHEMICAL RESEARCH IN CHINESE UNIVERSITIES （ 影响因子：1.307； 五年影响因子：0.979 ）

ISSN： 1005-9040

年卷期： 2015 年 31 卷 2 期

页码：

收录情况： SCI

摘要： Sulfonylureas(SUs) are potent and selective inhibitors of acetohydroxyacid synthase and has been used as herbicides. Some SUs also displayed other biological activities. In order to discuss the antifungal activity of SUs, a series of novel SUs containing aryl-substituted pyrimidine moieties was designed and synthesized. The preliminary bioassay showed that the title compounds exhibited moderate to favorable fungicidal activities in vivo. Especially, compound 9b exhibited more efficacy than the controls against five fungi at 25 mg/L. These promising results indicate that an aryl group on pyrimidine ring is favorable for antifungal activity and SUs are potential inhibitors for some phytopathogenic fungi.

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