Safety evaluation of a triazine compound nitromezuril by assessing bacterial reverse mutation, sperm abnormalities, micronucleus and chromosomal aberration

文献类型： 外文期刊

第一作者： Fei, Chenzhong

作者： Fei, Chenzhong;Wang, Xiaoyang;Zhang, Keyu;Zhang, Lifang;Zheng, Wenli;Wang, Mi;Li, Tao;Xiao, Sui;Xue, Feiqun;Wang, Chunmei;Zhang, Jie;Lin, Yang

作者机构：

关键词： Coccidiosis;Anticoccidials;Nitromezuril;Bacterial reverse mutation (Ames);Sperm abnormalities;Bone marrow micronucleus;Chromosome aberration

期刊名称：REGULATORY TOXICOLOGY AND PHARMACOLOGY （ 影响因子：3.271； 五年影响因子：4.291 ）

ISSN： 0273-2300

年卷期： 2015 年 71 卷 3 期

页码：

收录情况： SCI

摘要： Nitromezuril (NZL) is a novel triazine compound that exhibits remarkable anticoccidial activity. However, mutagenicity and genotoxicity of NZL have not been evaluated to date. This study evaluated the potential risks of NZL by testing for bacterial reverse mutation (Ames), mouse sperm abnormality (SA), bone marrow micronucleus (MN) and chromosomal aberration (CA). Mice were orally administered with NZL at 385, 192 and 96 mg/kg, corresponding to 0.5x, 0.25x and 0.125x the LD50 of NZL, respectively. No significant increases in SA and CA were found in mice treated with NZL for 5 d and 3 d, respectively (P > 0.05). NZL at 96-385 mg/kg did not have significant influence on micronucleated polychromatic erythrocyte counts (P > 0.05). These results suggest that NZL is not genotoxic. However, Ames test results were positive both with and without the S9 system for Salmonella typhimurium TA98 and TA100, suggesting that NZL may be mutagenic. The mutagenic effects of NZL were different in in vitro and in vivo assays. Further studies should be conducted to confirm the safety of using and developing NZL as a novel anticoccidial drug. (C) 2015 Published by Elsevier Inc.

分类号：

  • 相关文献

[1]Action of nitromezuril against Eimeria tenella with clinically anticoccidial indices and histopathology. She, Rufeng,Fei, Chenzhong,Chen, Huiya,Wang, Xiaoyang,Wang, Mi,Zhang, Keyu,Zhang, Lifang,Wang, Chunmei,Liu, Yingchun,Zheng, Wenli,Xue, Feiqun.

[2]Anticoccidial effects of a novel triazine nitromezuril in broiler chickens. Fei, Chenzhong,Fan, Chao,Zhao, Qiping,Wang, Xiaoyang,Zheng, Wenli,Wang, Mi,Zhang, Keyu,Zhang, Lifang,Li, Tao,Xue, Feiqun,Lin, Yang. 2013

[3]The complete mitochondrial genome sequence of Eimeria mitis (Apicomplexa: Coccidia). Liu, Guo-Hua,Hou, Jie,Song, Hui-Qun,Zhu, Xing-Quan,Liu, Guo-Hua,Zhu, Xing-Quan,Hou, Jie,Weng, Ya-Biao,Li, Shu,Yuan, Zi-Guo,Lin, Rui-Qing,Zhu, Xing-Quan.

[4]Coccidiosis immunization: Effects of mushroom and herb polysaccharides on immune responses of chickens infected with Eimeria tenella. Guo, FC,Kwakkel, RP,Williams, BA,Suo, X,Li, WK,Verstegen, MWA. 2005

[5]The complete mitochondrial genome sequence of Eimeria magna (Apicomplexa: Coccidia). Tian, Si-Qin,Wang, Chun-Ren,Zhu, Xing-Quan,Tian, Si-Qin,Liu, Guo-Hua,Zhu, Xing-Quan,Cui, Ping,Fang, Su-Fang,Liu, Guo-Hua,Zhu, Xing-Quan. 2015

[6]Prevalence of Coccidiosis in Domestic Rabbits (Oryctolagus cuniculus) in Northwest China. Qiao, J.,Meng, Q. L.,Chen, C. F.,Wang, J. W.,Wang, W. S.,Zhang, Z. C.,Cai, K. J.,Yang, L. H.,Qiao, J.,Cai, X. P.,Tian, G. F.. 2012

[7]Anticoccidial effects of areca nut (Areca catechu L.) extract on broiler chicks experimentally infected with Eimeria tenella. Wang, Dingfa,Zhou, Luli,Li, Wei,Zhou, Hanlin,Hou, Guanyu,Li, Wei. 2018

[8]Pathogenic effects of the coccidium Eimeria ninakohlyakimovae in goats. Dai, YB,Liu, XY,Liu, M,Tao, JP. 2006

[9]Functional characterizations of malonyl-CoA:acyl carrier protein transacylase (MCAT) in Eimeria tenella. Zhu, Guan,Sun, Mingfei,Qin, Zonghua,Wu, Caiyan,Lv, Minna,Liao, Shenquan,Qi, Nanshan,Xie, Mingquan,Cai, Jianping,Sun, Mingfei,Qin, Zonghua,Wu, Caiyan,Lv, Minna,Liao, Shenquan,Qi, Nanshan,Xie, Mingquan,Cai, Jianping.

[10]Anticoccidial effect of Piper sarmentosum extracts in experimental coccidiosis in broiler chickens. Wang, Dingfa,Zhou, Luli,Li, Wei,Zhou, Hanlin,Hou, Guanyu,Li, Wei.

作者其他论文 更多>>

微信小程序