Epidemiology and biological characteristics of influenza A (H4N6) viruses from wild birds

文献类型： 外文期刊

第一作者： Song, Xingdong

作者： Song, Xingdong;Tian, Jingman;Li, Minghui;Bai, Xiaoli;Zhao, Zhiguo;Shi, Jianzhong;Zeng, Xianying;Tian, Guobin;Guan, Yuntao;Li, Yanbing;Chen, Hualan;Chai, Hongliang

作者机构：

关键词： epidemiology; phylogeny; receptor binding property; replicative ability; pathogenicity

期刊名称：EMERGING MICROBES & INFECTIONS （ 影响因子：7.5； 五年影响因子：7.2 ）

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年卷期： 2024 年 13 卷 1 期

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收录情况： SCI

摘要： During the active surveillance, we isolated nine H4N6 subtype influenza A viruses from wild birds in China. To reveal the epidemiology and biology characteristics of H4 subtype influenza A virus from wild birds, we investigated H4 subtype viruses available in the public source, and found that the H4 viruses have been detected in at least 37 countries to date, and more than 73.6% of the viruses were from wild Anseriformes. Bayesian phylogeographic analysis showed that Mongolia worked as the important transmission centre for Eurasian lineage H4 viruses spreading. Phylogenetic analysis of HA genes indicated that global H4 influenza A viruses were divided into Eurasian and North American lineage, our nine H4N6 isolates fell into the Eurasian lineage. Recombination analysis suggested that nine H4N6 isolates underwent complex gene recombination with various subtypes of influenza A viruses and formed two genotypes. Notably, nine H4N6 isolates acquired mammalian virulence-increasing residues. Two representative H4N6 viruses possessed dual receptor binding specificity, they could efficiently replicate in MDCK and 293 T cells in vitro infection, also could cross the species barrier to infect mice directly without prior adaption in vivo experiments. These findings emphasize the public health issues represented by H4 viruses, and highlight the need to strengthen the active surveillance of H4 viruses from wild birds.

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