Emulsion-coaxial electrospinning: The role of zein as a shell layer in multicore-shell structured nanofibers for bioactive delivery

文献类型： 外文期刊

第一作者： Zhang, Cen

作者： Zhang, Cen;Li, Sicheng;Chen, Di;Lu, Wenjing;Xiao, Chaogeng

作者机构：

关键词： Gelatin; Zein; Emulsion-coaxial electrospinning; Multicore-shell nanofibers; Encapsulation; Sustained release

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 306 卷

页码：

收录情况： SCI

摘要： Multicore-shell nanofibers were fabricated by integrating emulsion electrospinning and coaxial electrospinning technologies, in which the multicore section of the nanofibers was prepared by electrospinning of gelatin- stabilized emulsions, and the shell layer was coaxially electrospun from zein solution. Coaxial electrospinning of zein helped form emulsion-based electrospun fibers with bead-in-string, spindle-like, and straight morphologies. The hydrogen bonding between gelatin and zein contributed to the enhanced thermal properties of coaxially electrospun nanofibers. The coating of zein as shell greatly improved fiber surface wettability and mechanical strength. The release behavior of curcumin from the nanofibers was dominated by Fickian diffusion, and the zein shell as a physical barrier favored the prolonged release of curcumin and then the long-lasting antibacterial activity towards Escherichia coli. This work thus gives an insight into the development of the nanofibers by emulsion-coaxial electrospinning as encapsulation matrices for the application in food products.

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