Polyketides with different post-modifications from desert endophytic fungus Paraphoma sp.

文献类型： 外文期刊

第一作者： Li, L. Y.

作者： Li, L. Y.;Wang, M. H.;Tan, X. M.;Zhang, X. Y.;Jia, H. M.;Zhang, H. W.;Zhang, T.;Zou, Z. M.;Ding, G.;Li, L. Y.;Wang, M. H.;Tan, X. M.;Zhang, X. Y.;Jia, H. M.;Zhang, H. W.;Zhang, T.;Zou, Z. M.;Ding, G.;Sun, B. D.;Zhang, G. S.;Deng, H.

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关键词： Polyketides;post-modifications;desert endophytic fungus;Paraphoma sp

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

ISSN： 1478-6419

年卷期： 2018 年 32 卷 8 期

页码：

收录情况： SCI

摘要： Three new polyketides 4,6,8-trihydroxy-5-methyl-3,4-dihydronaphthalen-1(2H)-one (1), 5,7-dihydroxy-3-(1-hydroxyethyl)-3,4-dimethylisobenzofuran-1(3H)-one (2) and 1-(4-hydroxy-6-methoxy-1,7-dimethyl-3-oxo-1,3-dihydroisobenzofuran-1-yl) ethyl acetate (3) together with seven known analogues (4-10) were isolated from desert endophytic fungus Paraphoma sp. The structures of these compounds were elucidated by analysis of NMR data. The absolute configuration of (1-3) was established on the basis of CD experiments. The possible biosynthetic pathway of compounds (1-10) was suggested, which implied that these secondary metabolites might be originated from polyketide biosynthesis with different post-modification reactions. Compounds 2, and 5-8 were evaluated for bioactivities against plant pathogen A. solani, whereas none of them displayed any biological effects. In addition, compounds 1, 2 and 5-10 were also tested for cytotoxic activities against three human cancer cell lines (HepG2 cells, MCF-7 cells and Hela cells) without biological effects. [GRAPHICS] .

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