Out of Southern East Asia of the Brown Rat Revealed by Large-Scale Genome Sequencing

文献类型: 外文期刊

第一作者: Li, Yan

作者: Li, Yan;Otecko, Newton O.;Liu, He-Qun;Wang, Ming-Shan;Irwin, David M.;Peng, Ming-Sheng;Wu, Dong-Dong;Zhang, Ya-Ping;Zeng, Lin;Su, Ling-Yan;Otecko, Newton O.;Liu, He-Qun;Wang, Ming-Shan;Peng, Ming-Sheng;Wu, Dong-Dong;Zhang, Ya-Ping;Ming, Chen;Li, Hai-Peng;Ming, Chen;Li, Yan;Zhang, Ya-Ping;Li, Yan;Yao, Yong-Gang;Su, Yan-Hua;Otecko, Newton O.;Peng, Ming-Sheng;Wu, Dong-Dong;Dalecky, Ambroise;Dalecky, Ambroise;Aplin, Ken;Donnellan, Stephen;Aplin, Ken;Liu, Xiao-Hui;Song, Ying;Zhang, Zhi-Bin;Esmailizadeh, Ali;Sohrabi, Saeed S.;Nanaei, Hojjat Asadollahpour;Atteynine, Solimane Ag;Atteynine, Solimane Ag;Rocamora, Gerard;Brescia, Fabrice;Morand, Serge;Irwin, David M.

作者机构:

关键词: Rattus norvegicus;origin;demographic history;natural selection

期刊名称:MOLECULAR BIOLOGY AND EVOLUTION ( 影响因子:16.24; 五年影响因子:18.67 )

ISSN: 0737-4038

年卷期: 2018 年 35 卷 1 期

页码:

收录情况: SCI

摘要: The geographic origin and migration of the brown rat (Rattus norvegicus) remain subjects of considerable debate. In this study, we sequenced whole genomes of 110 wild brown rats with a diverse world-wide representation. We reveal that brown rats migrated out of southern East Asia, rather than northern Asia as formerly suggested, into the Middle East and then to Europe and Africa, thousands of years ago. Comparison of genomes from different geographical populations reveals that many genes involved in the immune system experienced positive selection in the wild brown rat.

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