The regulation of inflammation and oxidative status against lung injury of residue polysaccharides by Lentinula edodes

文献类型： 外文期刊

第一作者： Ren, Zhenzhen

作者： Ren, Zhenzhen;Song, Xinling;Zhang, Jianjun;Wang, Wenshuai;Wang, Xiuxiu;Gao, Zheng;Jing, Huijuan;Li, Shangshang;Jia, Le;Li, Juan

作者机构：

关键词： Anti-inflammatory effects;Antioxidative effects;Enzymatic- and acidic-polysaccharides;Lentinula edodes residue;Lung injury

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2018 年 106 卷

页码：

收录情况： SCI

摘要： In present study, two hydrolyzed residue polysaccharides (RPS) of enzymatic-RPS (ERPS) and acidic-RPS (ARPS) were successfully obtained from the residue of Lentinula edodes, and the anti-inflammatory as well as antioxidative effects on lipopolysaccharide-induced (LPS-induced) lung injured mice were investigated. The results demonstrated that ERPS showed superior lung protective effects by ameliorating the lung wet-to-dry weight (W/D) ratio, reducing the TNF-alpha, IL-6, and IL-1 beta levels in BALF, lowing the pulmonary MPO activity, decreasing the serum C3 and hs-CPR contents, as well as improving the antioxidant status by enhancing pulmonary enzyme activities (SOD, GSH-Px, CAT, and T-AOC) and eliminating the lipid peroxidation (MDA and LPO), respectively. These conclusions indicated that both RPS and its hydrolysates (ARPS and ERPS) might be suitable for functional foods and a potentially effective candidate medicine for the treatment of lung injury. (C) 2017 Elsevier B.V. All rights reserved.

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