Molecularly imprinted polymer-based electrochemical sensor for rapid detection of masked deoxynivalenol with Mn-doped CeO2 nanozyme as signal amplifier

文献类型： 外文期刊

第一作者： Nie, Dongxia

作者： Nie, Dongxia;Zhu, Xueting;Liu, Minghui;Cheng, Meng;Fan, Kai;Zhao, Zhihui;Huang, Qingwen;Han, Zheng;Zhang, Xiaolin

作者机构：

关键词： Deoxynivalenol-3-glucoside; Molecularly imprinted polymer; Electrochemical sensor; Mn-CeO 2; Nanozyme

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：12.2； 五年影响因子：11.9 ）

ISSN： 0304-3894

年卷期： 2024 年 477 卷

页码：

收录情况： SCI

摘要： Deoxynivalenol-3-glucoside (D3G), the masked form of the important mycotoxin deoxynivalenol (DON), displays potential toxicity but is difficult to control owing to the lack of rapid detection methods. Herein, an innovative molecularly imprinted polymer (MIP)-based electrochemical sensor was developed for the rapid detection of D3G. MIP, an efficient recognition element for D3G, was electropolymerized using o-phenylenediamine based on a surface functional monomer-directing strategy for the first time. CeO2, 2 , which contains both Ce3+ 3 + and Ce4+ 4 + oxidation states, was introduced as a nanozyme to catalyze H2O2 2 O 2 reduction, while Mn doping generated more oxygen vacancies and considerably improved the catalytic activity. Mn-CeO2 2 also served as a promising substrate material because of its large surface area and excellent conductivity. Under optimal conditions, a good linear relationship was observed for D3G detection over the concentration range of 0.01-50 ng/mL. The proposed sensor could detect D3G down to 0.003 ng/mL with excellent selectivity, even distinguishing its precursor DON in complex samples. The sensor exhibited acceptable stability with high reproducibility and accuracy, and could successfully determine D3G in grain samples. To the best of our knowledge, this is the first electrochemical sensing platform for rapid D3G detection that can easily be expanded to other masked mycotoxins.

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