Metabolic Profile of Zearalenone in Liver Microsomes from Different Species and Its in Vivo Metabolism in Rats and Chickens Using Ultra High-Pressure Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry

文献类型： 外文期刊

第一作者： Yang, Shupeng

作者： Yang, Shupeng;Zhang, Jinzhen;Jin, Yue;Zhou, Jinhui;Li, Yi;Yang, Shupeng;Zhang, Huiyan;De Ruyck, Karl;De Saeger, Sarah;De Boevre, Marthe;Yang, Shupeng;Zhang, Huiyan;Sun, Feifei;Wang, Zhanhui;Zhang, Suxia;Li, Yanshen

作者机构：

关键词： zearalenone;metabolism;biotransformation;phase I and phase II

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2017 年 65 卷 51 期

页码：

收录情况： SCI

摘要： To explore differences of zearalenone (ZEN) metabolism between various species, phase I and II metabolism by liver microsomes of animals and human were investigated using ultra high-pressure liquid chromatography-quadrupole/time-offlight mass spectrometry (UHPLC-Q/TOF MS). A total of 24 metabolites were identified, among which 12 were reported for the first time. Reduction, hydroxylation, and glucuronidation were the major metabolic pathways of ZEN, and significant differences in various species were also observed. Reduction was the main reaction in swine and human, whereas hydroxylation was predominant in rats, chickens, goats, and cows in in vitro systems. Furthemore, in vivo metabolism of ZEN in rats and chickens was investigated, and 23 and 6 metabolites were identified in each species, respectively. Reduction, hydroxylation, and glucuronidation were the major metabolic pathways in rats, while reduction and sulfation predominated in chickens. These results further enrich the biotransformation profile of ZEN, providing a helpful reference for assessing the risks to animals and humans.

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