Gene engineering in swine for agriculture

文献类型： 外文期刊

第一作者： Wang Yan-fang

作者： Wang Yan-fang;Huang Jiao-jiao;Zhao Jian-guo;Zhao Jian-guo

作者机构：

关键词： gene engineering;genome editing;pig;agricultural application

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 影响因子：2.848； 五年影响因子：2.979 ）

ISSN： 2095-3119

年卷期： 2017 年 16 卷 12 期

页码：

收录情况： SCI

摘要： Domestic pigs are the second most important source of meat world-wide, and the genetic improvement of economic traits, such as meat production, growth, and disease resistance, is a critical point for efficient production in pigs. Through conventional breeding and selection programs in pigs, which are painstakingly slow processes, some economic traits, such as growth and backfat, have been greatly improved over the past several decades. However, the improvement of many polygenetic traits is still very slow and challenging to be improved by conventional breeding strategies. The development of reproductive knowledge and a variety of techniques, including foreign gene transfer strategies, somatic cell nuclear transfer (SCNT) and particularly, recently developed nuclease-mediated genome editing tools, has provided efficient ways to produce genetically modified (GM) pigs for the dramatic improvement of economic traits. In this review, we briefly discuss the progress of genomic markers used in pig breeding program, trace the history of genetic engineering, mainly focusing on the progress of recently developed genome editing tools, and summarize the GM pigs which have been generated to aim at the agricultural purposes. We also discuss the specific challenges facing application of gene engineering in pig breeding, and future prospects.

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