Epigallocatechin gallate-beta-lactoglobulin nanoparticles improve the antitumor activity of EGCG for inducing cancer cell apoptosis

文献类型： 外文期刊

第一作者： Wu, Min

作者： Wu, Min;Jin, Peng;Qin, Dingkui;Wang, Kai;Du, Qizhen;Jin, Jianchang;Xu, Yongquan;Yin, Junfeng

作者机构：

关键词： (-)Epigallocatechin-3-gallate (EGCG);beta-lactoglobulin;Nanoparticles;Cancer cells;Proliferative inhibition;Bioactivity

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2017 年 39 卷

页码：

收录情况： SCI

摘要： (-)-Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, is a potent antioxidant with numerous reported health benefits, such as anti-proliferative and pro-apoptotic effects. We combined thermally modified beta-lactoglobulin (beta-LG) with EGCG to form stable co-assembled nanoparticles (E beta-NPs). The E beta-NPs inhibited the proliferation of human malignant melanoma cells A375 and human eosophageal carcinoma cells TE-1 with 69.0% and 63.7% greater activity than EGCG, respectively. Cancer cells treated with E beta-NPs showed increased apoptosis, suppressed proliferation and appreciable cell cycle inhibition. A plausible mechanism of E beta-NPs induced apoptosis was proposed, in which E beta-NPs were more effective than native EGCG for Akt-mediated phosphorylation, which altered several pro/anti-apoptotic proteins including Bcl-2 family members and caspases. Thus, E beta-NPs have the potential to improve the chemopreventive effect of EGCG in functional foods.

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