A natural gene drive system confers reproductive isolation in rice

文献类型： 外文期刊

第一作者： Wang, Chaolong

作者： Wang, Chaolong;Lu, Jiayu;Zhao, Zhigang;Yu, Xiaowen;Hu, Yang;He, Xiaodong;Li, Chao;Miao, Rong;Zhang, Yunhui;Tang, Weijie;Wang, Yunlong;Hao, Benyuan;Wang, Qiming;Cheng, Siqi;He, Xiaojuan;Yao, Bowen;Gao, Junwen;Zhu, Xufei;Yu, Hao;Wang, Yong;Sun, Yan;Zhou, Chunlei;Dong, Hui;Liu, Xi;Tian, Yunlu;Liu, Shijia;Wang, Chunming;Jiang, Ling;Wan, Jianmin;Wang, Chaolong;Wang, Jian;Xiong, Yehui;Zheng, Xiaoming;Lin, Qibing;Ren, Yulong;Ma, Xiaoding;Guo, Xiuping;Cheng, Zhijun;Wang, Haiyang;Wu, Chuanyin;Wan, Jianmin;Xiong, Yehui;Chai, Jijie;Li, Jing;Zhou, Jiawu;Tao, Dayun;Zeng, Yonglun;Zhu, Ying;Jiang, Liwen;Ren, Yulong;Zhu, Ying;Jiang, Liwen;Guo, Mali;Zhang, Wei;Zhang, Bosen;Guo, Huishan

作者机构： Nanjing Agr Univ, State Key Lab Crop Genet & Germplasm Enhancement &, Nanjing 210095, Peoples R China;Chinese Acad Agr Sci, Inst Crop Sci, State Key Lab Crop Gene Resources & Breeding, Beijing 100081, Peoples R China;Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Tsinghua Peking Joint Ctr Life Sci, Sch Life Sci, Beijing 100084, Peoples R China;Yunnan Acad Agr Sci, Food Crops Res Inst, Kunming 650200, Peoples R China;Chinese Univ Hong Kong, Sch Life Sci, Ctr Cell & Dev Biol, Shatin, Hong Kong, Peoples R China;Chinese Univ Hong Kong, Sch Life Sci, State Key Lab Agrobiotechnol, Shatin, Hong Kong, Peoples R China;Nanjing Agr Univ, Coll Anim Sci & Technol, Nanjing 210095, Peoples R China;Chinese Acad Sci, Inst Microbiol, State Key Lab Plant Genom, Beijing 100101, Peoples R China

期刊名称：CELL （ 2022影响因子：64.5； 五年影响因子：57.5 ）

ISSN： 0092-8674

年卷期： 2023 年 186 卷 17 期

页码：

收录情况： SCI

摘要： Hybrid sterility restricts the utilization of superior heterosis of indica-japonica inter-subspecific hybrids. In this study, we report the identification of RHS12, a major locus controlling male gamete sterility in indica- japonica hybrid rice. We show that RHS12 consists of two genes (iORF3/DUYAO and iORF4/JIEYAO) that confer preferential transmission of the RHS12-i type male gamete into the progeny, thereby forming a natural gene drive. DUYAO encodes a mitochondrion-targeted protein that interacts with OsCOX11 to trigger cyto-toxicity and cell death, whereas JIEYAO encodes a protein that reroutes DUYAO to the autophagosome for degradation via direct physical interaction, thereby detoxifying DUYAO. Evolutionary trajectory analysis re-veals that this system likely formed de novo in the AA genome Oryza clade and contributed to reproductive isolation (RI) between different lineages of rice. Our combined results provide mechanistic insights into the genetic basis of RI as well as insights for strategic designs of hybrid rice breeding.

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