The pH stability of foot-and-mouth disease virus

文献类型: 外文期刊

第一作者: Yuan, Hong

作者: Yuan, Hong;Li, Pinghua;Ma, Xueqing;Lu, Zengjun;Sun, Pu;Bai, Xingwen;Zhang, Jing;Bao, Huifang;Cao, Yimei;Li, Dong;Fu, Yuanfang;Chen, Yingli;Zhang, Jie;Liu, Zaixin;Bai, Qifeng

作者机构:

关键词: FMDV;pH stability;Substitutions;Uncoating

期刊名称:VIROLOGY JOURNAL ( 影响因子:4.099; 五年影响因子:3.719 )

ISSN: 1743-422X

年卷期: 2017 年 14 卷

页码:

收录情况: SCI

摘要: This review summarized the molecular determinants of the acid stability of FMDV in order to explore the uncoating mechanism of FMDV and improve the acid stability of vaccines. Background: The foot-and-mouth disease virus (FMDV) capsid is highly acid labile and tends to dissociate into pentameric subunits at acidic condition to release viral RNA for initiating virus replication. However, the acid stability of virus capsid is greatly required for the maintenance of intact virion during the process of virus culture and vaccine production. The conflict between the acid lability in vivo and acid stability in vitro of FMDV capsid promotes the selection of a series of amino acid substitutions which can confer resistance to acid-induced FMDV inactivation. In order to explore the uncoating activity of FMDV and enhance the acid stability of vaccines, we summarized the available works about the pH stability of FMDV. Main body of the abstract: In this review, we analyzed the intrinsic reasons for the acid instability of FMDV from the structural and functional aspects. We also listed all substitutions obtained by different research methods and showed them in the partial capsid of FMDV. We found that a quadrangle region in the viral capsid was the place where a great many pH-sensitive residues were distributed. As the uncoating event of FMDV is dependent on the pH-sensitive amino acid residues in the capsid, this most pH-sensitive position indicates a potential candidate location for RNA delivery triggered by the acid-induced coat disassociation. Short conclusion: This review provided an overview of the pH stability of FMDV. The study of pH stability of FMDV not only contributes to the exploration of molecule and mechanism information for FMDV uncoating, but also enlightens the development of FMDV vaccines, including the traditionally inactivated vaccines and the new VLP (virus-like particle) vaccines.

分类号:

  • 相关文献

[1]Comparison of immune responses against foot-and-mouth disease virus induced by fusion proteins using the swine IgG heavy chain constant region or beta-galactosidase as a carrier of immunogenic epitopes. Li, GJ,Chen, WZ,Yan, WY,Zhao, K,Liu, MQ,Zhang, J,Fei, L,Xu, QX,Sheng, ZT,Lu, YG,Zheng, ZX.

[2]Thermostability Improvement of a Streptomyces Xylanase by Introducing Proline and Glutamic Acid Residues. Wang, Kun,Luo, Huiying,Huang, Huoqing,Shi, Pengjun,Hua, Huifang,Wang, Caihong,Wang, Shuanghe,Yao, Bin,Tian, Jian,Turunen, Ossi.

[3]Substitutions in Spodoptera exigua topoisomerase I modulate its relaxation activity and camptothecin sensitivity. Zhang, Lan,Zhang, Yanning,Mao, Liangang,Jiang, Hongyun.

[4]Virulence of an H5N8 highly pathogenic avian influenza is enhanced by the amino acid substitutions PB2 E627K and HA A149V. Wu, Haibo,Peng, Xiuming,Liu, Fumin,Cheng, Linfang,Lu, Xiangyun,Yao, Hangping,Wu, Nanping,Lu, Rufeng,Xu, Lihua.

[5]Symbiotic Streptomyces sp. TN119 GH 11 xylanase: a new pH-stable, protease- and SDS-resistant xylanase. Zhou, Junpei,Shi, Pengjun,Zhang, Rui,Huang, Huoqing,Meng, Kun,Yang, Peilong,Yao, Bin. 2011

[6]A new xylanase from thermoacidophilic Alicyclobacillus sp A4 with broad-range pH activity and pH stability. Bai, Yingguo,Wang, Jianshe,Yang, Peilong,Shi, Pengjun,Luo, Huiying,Meng, Kun,Huang, Huoqing,Yao, Bin,Zhang, Zhifang.

[7]Engineering a highly active thermophilic beta-glucosidase to enhance its pH stability and saccharification performance. Xia, Wei,Shi, Pengjun,Bai, Yingguo,Luo, Huiying,Ma, Rui,Yao, Bin,Xia, Wei,Qian, Lichun,Xu, Xinxin. 2016

[8]A novel xylanase, XynA4-2, from thermoacidophilic Alicyclobacillus sp A4 with potential applications in the brewing industry. Wang, Jianshe,Bai, Yingguo,Shi, Pengjun,Luo, Huiying,Huang, Huoqing,Yao, Bin,Wang, Jianshe,Yin, Jun. 2011

[9]Immune responses of recombinant adenovirus co-expressing VP1 of foot-and-mouth disease virus and porcine interferon alpha in mice and guinea pigs. Du, Yijun,Dai, Jianjun,Li, Yufeng,Duan, Shuyi,Jiang, Ping,Li, Congzhi,Qi, Jing. 2008

[10]Foot-and-mouth disease virus carrier status in Bos grunniens yaks. Chang, Huiyun,Ma, Yanbin,Lin, Tong,Cong, Guozheng,Du, Junzheng,Ma, Jinling. 2013

[11]The silent point mutations at the cleavage site of 2A/2B have no effect on the self-cleavage activity of 2A of foot-and-mouth disease virus. Gao, Zong-liang,Zhou, Jian-hua,Zhang, Jie,Ding, Yao-zhong,Liu, Yong-sheng.

[12]Chimeric virus-like particles elicit protective immunity against serotype O foot-and-mouth disease virus in guinea pigs. Liu, Xinsheng,Fang, Yuzhen,Zhou, Peng,Lu, Yanzhen,Zhang, Qiaoling,Xiao, Shuai,Dong, Zhaoliang,Pan, Li,Lv, Jianliang,Zhang, Zhongwang,Zhang, Yongguang,Wang, Yonglu,Liu, Xinsheng,Fang, Yuzhen,Zhou, Peng,Lu, Yanzhen,Zhang, Qiaoling,Xiao, Shuai,Dong, Zhaoliang,Pan, Li,Lv, Jianliang,Zhang, Zhongwang,Zhang, Yongguang,Wang, Yonglu,Lu, Yanzhen,Xiao, Shuai.

[13]Bovine fetal epithelium cells expressing shRNA targeting viral VP1 gene resisted against foot-and-mouth disease virus. Wang, Hongmei,Liu, Xiao,Wu, Jianming,Wu, Gang,Yang, Huiting,Xie, Weixin,He, Hongbin,Yu, Li,He, Chenqiang,Xia, Xianzhu.

[14]Nucleotide mismatches of foot-and-mouth disease virus during replication. Ma, Y. B.,Hao, C. X.,Chang, H. Y.. 2013

[15]Poly(I:C) combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs. Cao, Yimei,Lu, Zengjun,Li, Yanli,Sun, Pu,Li, Dong,Li, Pinghua,Bai, Xingwen,Fu, Yuanfang,Bao, Huifang,Zhou, Chunxue,Xie, Baoxia,Chen, Yingli,Liu, Zaixin. 2013

[16]Foot-and-mouth disease virus infection stimulates innate immune signaling in the mouse macrophage RAW 264.7 cells. Zhi, Xiaoying,Gao, Yuan,Wu, Run,Zhi, Xiaoying,Lv, Jianliang,Wei, Yanquan,Du, Ping,Chang, Yanyan,Zhang, Yun,Gao, Yuan,Zhi, Xiaoying,Lv, Jianliang,Wei, Yanquan,Du, Ping,Chang, Yanyan,Zhang, Yun,Gao, Yuan,Gao, Yuan. 2018

[17]Foot-and-mouth disease vaccines: progress and problems. Cao, Yimei,Lu, Zengjun,Liu, Zaixin.

[18]Sequencing and analysis for the full-length genome RNA of foot-and-mouth disease virus China/99. Zhang, XS,Liu, ZX,Zhao, QZ,Chang, HY,Xie, QG.

[19]Expression of foot-and-mouth disease virus epitopes in tobacco by a tobacco mosaic virus-based vector. Wu, LG,Jiang, LB,Zhou, ZA,Fan, JH,Zhang, QQ,Zhu, HH,Han, Q,Xu, ZK.

[20]Novel chimeric foot-and-mouth disease virus-like particles harboring serotype O VP1 protect guinea pigs against challenge. Li, Haitao,Li, Zhiyong,Xie, Yinli,Qin, Xiaodong,Qi, Xingcai,Sun, Peng,Bai, Xingwen,Zhang, Zhidong,Li, Haitao,Ma, Youji.

作者其他论文 更多>>