Identification of selection signals by large-scale whole-genome resequencing of cashmere goats

文献类型： 外文期刊

第一作者： Li, Xiaokai

作者： Li, Xiaokai;Su, Rui;Zhang, Wenguang;Qiao, Xian;Fan, Yixing;Zhang, Yanjun;Wang, Ruijun;Liu, Zhihong;Wang, Zhiying;Li, Jinquan;Su, Rui;Zhang, Yanjun;Wang, Ruijun;Liu, Zhihong;Wang, Zhiying;Li, Jinquan;Su, Rui;Zhang, Yanjun;Wang, Ruijun;Liu, Zhihong;Wang, Zhiying;Li, Jinquan;Su, Rui;Zhang, Yanjun;Wang, Ruijun;Liu, Zhihong;Wang, Zhiying;Li, Jinquan;Su, Rui;Wang, Wen;Wan, Wenting;Jiang, Huaizhi;Liu, Bin;Ma, Yuehui;Zhao, Qianjun;Di, Ran;Zhang, Hongping;Zhong, Tao;Jiang, Yu;Chen, Wei;Dong, Yang;Dong, Yang;Chen, Wei;Dong, Yang

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2017 年 7 卷

页码：

收录情况： SCI

摘要： Inner Mongolia and Liaoning cashmere goats are two outstanding Chinese multipurpose breeds that adapt well to the semi-arid temperate grassland. These two breeds are characterized by their soft cashmere fibers, thus making them great models to identify genomic regions that are associated with cashmere fiber traits. Whole-genome sequencing of 70 cashmere goats produced more than 5.52 million single-nucleotide polymorphisms and 710,600 short insertions and deletions. Further analysis of these genetic variants showed some population-specific molecular markers for the two cashmere goat breeds that are otherwise phenotypically similar. By analyzing F-ST and theta(pi) outlier values, we identified 135 genomic regions that were associated with cashmere fiber traits within the cashmere goat populations. These selected genomic regions contained genes, which are potential involved in the production of cashmere fiber, such as FGF5, SGK3, IGFBP7, OXTR, and ROCK1. Gene ontology enrichment analysis of identified short insertions and deletions also showed enrichment in keratinocyte differentiation and epidermal cell differentiation. These findings demonstrate that this genomic resource will facilitate the breeding of cashmere goat and other Capra species in future.

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