Oleanane-Type Saponins from the Roots of Ligulariopsis shichuana and Their alpha-Glucosidase Inhibitory Activities

文献类型： 外文期刊

第一作者： Liu, Ting-Ting

作者： Liu, Ting-Ting;Wang, Wen-Shu;Feng, Jin-Chao;Tian, Hong-Mei;Liu, Ting-Ting

作者机构：

关键词： Ligulariopsis shichuana;oleanane-type saponins;alpha-glucosidase inhibitory

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN： 1420-3049

年卷期： 2017 年 22 卷 11 期

页码：

收录情况： SCI

摘要： Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of Ligulariopsis shichuana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast alpha-glucosidase inhibitory effects and exhibited potent inhibition against alpha-glucosidase, while compounds 1 and 2 showed excellent inhibitory activities. The 3-O-glycoside moiety in oleanane-type saponin is important for the alpha-glucosidase inhibitory effects.

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