Genomic characterization of a bovine viral diarrhea virus 1 isolate from swine

文献类型： 外文期刊

第一作者： Deng, Yu

作者： Deng, Yu;Shan, Tong-Ling;Tong, Wu;Zheng, Xu-Chen;Guo, Yi-Yei;Zheng, Hao;Tong, Guang-Zhi;Cao, San-Jie;Wen, Xin-Tian

作者机构：

期刊名称：ARCHIVES OF VIROLOGY （ 影响因子：2.574； 五年影响因子：2.466 ）

ISSN： 0304-8608

年卷期： 2014 年 159 卷 9 期

页码：

收录情况： SCI

摘要： The SD0803 strain of the bovine viral diarrhea virus (BVDV) was isolated from a piglet in China in 2008 and has been classified as a novel subgenotype of BVDV-1. To describe the molecular features of this novel subgenotype, we sequenced and characterized the complete genome of the SD0803 virus. The genome is 12,271 bp in length and contains 5' and 3' untranslated regions (UTRs) that flank an open reading frame (ORF) encoding a 3,898-amino-acid polypeptide. The full-length genome of the SD0803 strain shares 78.8 % to 83.3 % identity with those of other BVDV-1 strains, 70.0 % to 70.7 % identity with those of BVDV-2 strains, and less than 67.6 % identity with those of other pestiviruses. The highest level of shared identity was 83.3 % between the complete SD0803 genome and that of the ZM-95 strain of BVDV-1. Phylogenetic analysis of the 5' UTR and the coding sequence for the N-terminal protease fragment of the SD0803 polyprotein indicated that the SD0803 virus is a member of the novel subgenotype BVDV-1q, isolates of which have been identified recently in dairy cattle and camels in China.

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