Glutathione S-transferase A1 (GSTA1) release, an early indicator of acute hepatic injury in mice

文献类型： 外文期刊

第一作者： Liu, Fangping

作者： Liu, Fangping;Lin, Yuexia;Li, Zhi;Ma, Xin;Han, Qing;Liu, Yingshu;Zhou, Qiong;Li, Rui;Li, Jichang;Gao, Li;Liu, Jingli

作者机构：

关键词： GSTA1;Acute hepatic injury;Time-response;Dose-response;Indicator

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2014 年 71 卷

页码：

收录情况： SCI

摘要： Three acute hepatic injury models (a CCl4-induced model, APAP-induced model and ethanol-induced model) in mice were used to study the importance of GSTA1 in acute hepatic injury by comparison with a standard enzyme marker, alanine aminotransferase (ALT). GSTA1 release was demonstrated to be an earlier and more sensitive indicator of hepatotoxicity than was ALT. Significant increases in GSTA1 were detected at 2 h after CCl4 exposure, while ALT was undetected at this time. GSTA1 was also a more sensitive indicator of hepatotoxicity than ALT after 6 h. In the APAP and ethanol models, GSTA1 was markedly increased earlier than ALT, at 2 h post exposure. The release of GSTA1 was significantly increased at a dose of 12.5 mg/kg (CCl4 model), 100 mg/kg (APAP model) and 10 ml/kg (ethanol model), the lowest exposure concentration for each model. In contrast, AST release was not statistically significant. These results suggest that GSTA1 can be detected at low concentrations during the early stages of acute hepatic injury and that GSTA1 is a more sensitive and more accurate indicator than ALT. (C) 2014 Elsevier Ltd. All rights reserved.

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