Improving intracellular uptake of 5-demethyltangeretin by food grade nanoemulsions

文献类型： 外文期刊

第一作者： Zheng, Jinkai

作者： Zheng, Jinkai;Li, Yan;Song, Mingyue;McClements, David Julian;Xiao, Hang;Zheng, Jinkai;Li, Yan;Fang, Xiang;Cao, Yong

作者机构：

关键词： 5-Demethyltangeretin;Polymethoxyflavones;Nanoemulsion;HCT116 cancer cells;Particle size;Uptake

期刊名称：FOOD RESEARCH INTERNATIONAL （ 影响因子：6.475； 五年影响因子：6.508 ）

ISSN： 0963-9969

年卷期： 2014 年 62 卷

页码：

收录情况： SCI

摘要： 5-Demethyltangeretin (5DT) is a unique citrus flavonoid that has been shown to have anti-cancer effects, but its low water-solubility and poor oral bioavailability may limit its application as a nutraceutical. In this study, we utilized emulsion-based delivery systems to increase the bioavailability of 5DT and its uptake by intestinal cancer cells. Oil-in-water emulsions with different mean droplet radii (r = 67, 125 and 203 nm) were fabricated using high-pressure homogenization. The amount of 5DT absorbed by intestinal cancer cells was quantified by HPLC using an electrochemistry detector. The relative percentages of 5DT absorption compared to a reference emulsion (r = 67 nm) were: 5.9% (in water, crystal); 13.1% (in medium chain triglyceride (MCT), crystal); 30.6% (emulsion, r = 203 nm); and 92.9% (emulsion, r = 125 nm). A cytotoxicity assay showed that 5DT encapsulated in smaller droplets produced stronger growth inhibition than those in larger droplets, and much higher than those dispersed in bulk MCT or bulk water. 5DT encapsulated within emulsions with small droplet sizes (nanoemulsions) produced higher cellular absorption and lower cancer cell viability. Our results suggested that this type delivery system may be useful for the application of 5DT and other similar nutraceuticals in functional foods and beverages. (C) 2014 Elsevier Ltd. All rights reserved.

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