Zymomonas mobilis: a novel platform for future biorefineries

文献类型： 外文期刊

第一作者： He, Ming Xiong

作者： He, Ming Xiong;Wu, Bo;Qin, Han;Tan, Fu Rong;Wang, Jing Li;Shui, Zong Xia;Dai, Li Chun;Zhu, Qi Li;Pan, Ke;Tang, Xiao Yu;Wang, Wen Guo;Hu, Qi Chun;He, Ming Xiong;Hu, Qi Chun;Ruan, Zhi Yong

作者机构：

关键词： Zymomonas mobilis;platform;biorefinery;biofuel;building block chemical

期刊名称：BIOTECHNOLOGY FOR BIOFUELS （ 影响因子：6.04； 五年影响因子：6.485 ）

ISSN： 1754-6834

年卷期： 2014 年 7 卷

页码：

收录情况： SCI

摘要： Biosynthesis of liquid fuels and biomass-based building block chemicals from microorganisms have been regarded as a competitive alternative route to traditional. Zymomonas mobilis possesses a number of desirable characteristics for its special Entner-Doudoroff pathway, which makes it an ideal platform for both metabolic engineering and commercial-scale production of desirable bio-products as the same as Escherichia coli and Saccharomyces cerevisiae based on consideration of future biomass biorefinery. Z. mobilis has been studied extensively on both fundamental and applied level, which will provide a basis for industrial biotechnology in the future. Furthermore, metabolic engineering of Z. mobilis for enhancing bio-ethanol production from biomass resources has been significantly promoted by different methods (i.e. mutagenesis, adaptive laboratory evolution, specific gene knock-out, and metabolic engineering). In addition, the feasibility of representative metabolites, i.e. sorbitol, bionic acid, levan, succinic acid, isobutanol, and isobutanol produced by Z. mobilis and the strategies for strain improvements are also discussed or highlighted in this paper. Moreover, this review will present some guidelines for future developments in the bio-based chemical production using Z. mobilis as a novel industrial platform for future biofineries.

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