Evaluation of Specific Pathogen-Free Ducks Infected with the Highly Pathogenic Avian Influenza Virus H5N1 Subtype Derived from Wild Birds

文献类型： 外文期刊

第一作者： Guan, Xueting

作者： Guan, Xueting;Chai, Hongliang;Wang, Yulong;Hua, Yuping;Li, Yanbing;Liu, Jingli;Guan, Xueting

作者机构：

关键词： Pathogenicity;highly pathogenic avian influenza virus (HPAIV);H5N1;SPF ducks;wild birds

期刊名称：PAKISTAN JOURNAL OF ZOOLOGY （ 影响因子：0.831； 五年影响因子：0.768 ）

ISSN： 0030-9923

年卷期： 2014 年 46 卷 3 期

页码：

收录情况： SCI

摘要： Wild birds of the Anseriformes and Gharadriiformes are, the natural hosts and reservoirs of avian influenza virus (AIV). These birds play a key role in the transmission of the highly pathogenic avian influenza virus (HPAIV) of the H5N1 subtype. The pathogenicity a H5N1 HPAIV in waterfowl appears to have increased. In this study, specific pathogen-free (SPF) ducks (Shaoxing sheldrake). of different ages were used as a model to imitate the natural infection with the H5N1 HPAIV. The results showed that 1-2 weeks old SPF ducks are not sensitive to the virus. However, the virus can replicate in the digestive and respiratory tracts of 3-6-weeks old SPF ducks. There was an inverse ratio between mortality and age (3 and 6 weeks old) of ducks, Although the amount of virus shed by 6-week-old SPF ducks was highest,the mortality rate. was the lowest The disease in ducks shows a range of degree of severity from mild clinical signs to mortality.. But the virus can replicate. to a high level in some vital organs (brain, pancreas and kidneys) which causes death directly. The high virus titer in the pancreas, may be related to the carriage, distribution and spread of the virus within ducks. This study has confirmed that there is a correlation between the pathogenicity of the H5N1 HPAIV and age of waterfowl. The data suggested that the degree of pathogenicity of the virus may be closely related to the development status of the duck's immune system.

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