A surrogate BSL2-compliant infection model recapitulating key aspects of human Marburg virus disease

文献类型： 外文期刊

第一作者： Yang, Wanying

作者： Yang, Wanying;Zhou, Wujie;Liang, Bo;Hu, Xiaojun;Wang, Shen;Wang, Zhenshan;Wang, Tiecheng;Xia, Xianzhu;Feng, Na;Zhao, Yongkun;Yan, Feihu;Yang, Wanying;Hu, Xiaojun;Wang, Zhenshan

作者机构：

关键词： Marburg virus; recombinant vesicular stomatitis virus; Syrian hamster; surrogate model; recurrence of classic symptoms; vaccine evaluation and drug screening

期刊名称：EMERGING MICROBES & INFECTIONS （ 影响因子：7.5； 五年影响因子：7.2 ）

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年卷期： 2025 年 14 卷 1 期

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收录情况： SCI

摘要： Marburg virus disease (MVD) is a severe infectious disease caused by the Marburg virus (MARV), posing a significant threat to humans. MARV needs to be operated under strict biosafety Level 4 (BSL-4) laboratory conditions. Therefore, accessible and practical animal models are urgently needed to advance prophylactic and therapeutic strategies for MARV. In this study, we constructed a recombinant vesicular stomatitis virus (VSV) expressing the Marburg virus glycoprotein (VSV-MARV/GP). Syrian hamsters infected with VSV-MARV/GP presented symptoms such as thrombocytopenia, lymphopenia, haemophilia, and multiorgan failure, developing a severe systemic disease akin to that observed in human MARV patients. Notably, the pathogenicity was found to be species-specific, age-related, sex-associated, and challenge route-dependent. Subsequently, the therapeutic efficacy of the MR191 monoclonal antibody was validated in this model. In summary, this alternative model is an effective tool for rapidly screening medical countermeasures against MARV GP in vivo under BSL-2 conditions.

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