A reassortment vaccine candidate as the improved formulation to induce protection against very virulent infectious bursal disease virus
文献类型: 外文期刊
第一作者: Qi, Xiaole
作者: Qi, Xiaole;Chen, Yuming;Ren, Xiangang;Zhang, Lizhou;Gao, Li;Wang, Nian;Qin, Liting;Wang, Yongqiang;Gao, Yulong;Wang, Xiaomei
作者机构:
关键词: Infectious bursal disease virus (IBDV);Reassortment;Vaccine;Reverse genetics
期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )
ISSN: 0264-410X
年卷期: 2014 年 32 卷 13 期
页码:
收录情况: SCI
摘要: Infectious bursal disease (IBD) is a highly contagious immunosuppressive disease affecting all major poultry producing areas of the world. Infectious bursal disease virus (IBDV) is genetically prone to mutation so that vaccines have to be changed accordingly. However, the traditional method of vaccine development with blind passage could not fit the style of the emergency prevention of IBDV. In this study, for the first time, a segment-reassortment attenuated IBDV rXATB, consisting of modified segment A of a prevalent strain and segment B of an attenuated strain, was designed and rescued; rXATB was stable and could induce good humoral and cellular immune responses which resulted in excellent protection against the lethal challenge of vvIBDV without obvious immunosuppression in chicken. This study revolutionarily provides a new formulation based on reverse genetics to develop new vaccine against prevalent IBDV. (C) 2014 Elsevier Ltd. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Genome-wide analysis of the FKBP gene family and the potential role of GhFKBP 13 in chloroplast biogenesis in upland cotton
作者:Liu, Jianguang;Geng, Zhao;Zhao, Guiyuan;Li, Mengzhe;An, Zetong;Zhang, Hanshuang;Wang, Yongqiang
关键词:
Gossypium hirsutum ;GhFKBP s; Chloroplast biogenesis; Starch and sucrose metabolism -
Adaptation of Diverse Maize Germplasm to Spring Season Conditions in Northeast China
作者:Li, Yi;Yang, Zhiyuan;Zhang, Fengyi;Zhang, Yuxing;Li, Mingshun;Zhang, Degui;Hao, Zhuanfang;Weng, Jianfeng;Li, Xinhai;Yong, Hongjun;Li, Yi;Yang, Zhiyuan;Shao, Yong;Jin, Zhenguo;Gao, Li;Nan, Yuantao;Yu, Yang
关键词:maize population; general combining ability; specific combining ability; Northeast China
-
Marek's disease virus protein kinase US3 inhibits DNA-sensing antiviral innate immunity via abrogating activation of NF-κB
作者:Li, Kai;Liu, Rui;Liu, Yongzhen;Gao, Li;Liu, Changjun;Zhang, Yanping;Qi, Xiaole;Cui, Hongyu;Wang, Suyan;Chen, Yuntong;Duan, Yulu;Gao, Yulong;Wang, Xiaomei;Li, Kai;Li, Kai;Wang, Xiaomei
关键词:Marek's disease virus; US3; innate immunity; DNA sensing; NF-kappa B
-
Long-Term Crop Rotation Revealed the Relationship Between Soil Organic Carbon Physical Fraction and Bacterial Community at Aggregate Scales
作者:Meng, Xianghai;Wang, Baicheng;Zhang, Xingzhe;Liu, Chunguang;Yang, Bing;Wang, Wenhui;Xu, Dehai;Zhang, Shuai;Wang, Xiaomei;Ji, Jinghong;Hao, Xiaoyu;Cao, Minghui;Wang, Yuming;Wang, Yuming
关键词:aggregate; bacterial community; long-term crop rotation; soil organic carbon
-
MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, Bombyx mori
作者:Ma, Chenkai;Xu, Fang;Hu, Chengjie;Yu, Wei;Xu, Xia;Ma, Chenkai;Xu, Fang;Hu, Chengjie;Cui, Chunguang;Du, Xin;Chen, Jine;Zhu, Linbao;Yu, Shaofang;He, Xingjian;Wang, Yongqiang;Xu, Xia
关键词:MPF; enzyme activity; embryo development; parthenogenesis;
Bombyx mori -
Identification of Thalictrum squarrosum as an alternate host for Puccinia triticina and pathogen analysis of Thalictrum squarrosum rust
作者:Zhao, Na;Huang, Liang;Ren, Jun;Yi, Ting;Li, Hongfu;Zhang, Hao;Liu, Bo;Gao, Li;Chen, Wanquan;Liu, Taiguo;Zhao, Na;Huang, Liang;Ren, Jun;Yi, Ting;Li, Hongfu;Zhang, Hao;Gao, Li;Chen, Wanquan;Liu, Taiguo;Zhang, Mengya;Yan, Hongfei;Liu, Taiguo
关键词:wheat leaf rust;
Puccinia triticina ;Thalictrum squarrosum ; alternate host; sexual reproduction -
Comparative Analyses of Gut Microbiomes in Hycleus cichorii (Coleoptera: Meloidae) Adults Reveal Their Distinct Microbes, Microbial Diversity and Composition Associated to Food
作者:Yi, Chunyan;Zhang, Cuicui;Wang, Yanping;Liu, Xu;Chen, Song;Gao, Li;Du, Chao;Yang, Yongli
关键词:feeding habits; food; full-length 16S rDNA; gut microbiota