A reassortment vaccine candidate as the improved formulation to induce protection against very virulent infectious bursal disease virus
文献类型: 外文期刊
第一作者: Qi, Xiaole
作者: Qi, Xiaole;Chen, Yuming;Ren, Xiangang;Zhang, Lizhou;Gao, Li;Wang, Nian;Qin, Liting;Wang, Yongqiang;Gao, Yulong;Wang, Xiaomei
作者机构:
关键词: Infectious bursal disease virus (IBDV);Reassortment;Vaccine;Reverse genetics
期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )
ISSN: 0264-410X
年卷期: 2014 年 32 卷 13 期
页码:
收录情况: SCI
摘要: Infectious bursal disease (IBD) is a highly contagious immunosuppressive disease affecting all major poultry producing areas of the world. Infectious bursal disease virus (IBDV) is genetically prone to mutation so that vaccines have to be changed accordingly. However, the traditional method of vaccine development with blind passage could not fit the style of the emergency prevention of IBDV. In this study, for the first time, a segment-reassortment attenuated IBDV rXATB, consisting of modified segment A of a prevalent strain and segment B of an attenuated strain, was designed and rescued; rXATB was stable and could induce good humoral and cellular immune responses which resulted in excellent protection against the lethal challenge of vvIBDV without obvious immunosuppression in chicken. This study revolutionarily provides a new formulation based on reverse genetics to develop new vaccine against prevalent IBDV. (C) 2014 Elsevier Ltd. All rights reserved.
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