Muscovy duck reovirus p10.8 protein localizes to the nucleus via a nonconventional nuclear localization signal

文献类型： 外文期刊

第一作者： Guo, Dongchun

作者： Guo, Dongchun;Qiu, Na;Shaozhou, Wulin;Bai, Xiaofei;He, Yilong;Zhang, Qingshan;Zhao, Jian;Liu, Ming;Zhang, Yun

作者机构：

关键词： Muscovy duck reocvirus;p10.8 protein;Nuclear localization signal

期刊名称：VIROLOGY JOURNAL （ 影响因子：4.099； 五年影响因子：3.719 ）

ISSN： 1743-422X

年卷期： 2014 年 11 卷

页码：

收录情况： SCI

摘要： Background: It was previously report that the first open reading frame of Muscovy duck reocvirus S4 gene encodes a 95-amino-acid protein, designed p10.8, which has no sequence similarity to other known proteins. Its amino acid sequence offers no clues about its function. Results: Subcellular localization and nuclear import signal of p10.8 were characterized. We found that p10.8 protein localizes to the nucleus of infected and transfected cells, suggesting that p10.8 nuclear localization is not facilitated by viral infection or any other viral protein. A functional non-canonical nuclear localization signal (NLS) for p10.8 was identified and mapped to N-terminus residues 1-40. The NLS has the ability to retarget a large cytoplasmic protein to the nucleus. Conclusions: p10.8 imported into the nucleus might via a nonconventional signal nuclear signal.

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