Neuroprotection effect of interleukin ( IL)-17 secreted by reactive astrocytes is emerged from a high-level IL-(17)-containing environment during acute neuroinflammation

文献类型： 外文期刊

第一作者： Hu, M. H.

作者： Hu, M. H.;Zheng, Q. F.;Jia, X. Z.;Li, Y.;Dong, Y. C.;Wang, C. Y.;Lin, Q. Y.;Zhang, F. Y.;Xu, H. W.;Ren, H.;Hu, M. H.;Zheng, Q. F.;Jia, X. Z.;Li, Y.;Dong, Y. C.;Wang, C. Y.;Lin, Q. Y.;Zhang, F. Y.;Xu, H. W.;Ren, H.;Zhao, R. B.;Zhou, J. H.;Yuan, H. P.;Zhang, W. H.

作者机构：

关键词： autoimmune response;experimental autoimmune uveitis;interleukin-17;neuroinflammation;neuroprotection;primary neurone culture

期刊名称：CLINICAL AND EXPERIMENTAL IMMUNOLOGY （ 影响因子：4.33； 五年影响因子：4.303 ）

ISSN： 0009-9104

年卷期： 2014 年 175 卷 2 期

页码：

收录情况： SCI

摘要： An increase in interleukin (IL)-17A-producing cells, particularly at sites of tissue inflammation, is observed frequently, yet the mechanism is not fully understood. This study aims to dissect the role of IL-17 in autoimmunity-mediated neuroinflammation. The cytokine milieu containing elevated IL-17, which often appears in active states of autoimmunity, was mimicked in vitro by a supernatant obtained from rat peripheral blood monocytes stimulated with phorbol mystistate acetate (PMA)/ionomycin. The application of such inflammatory media on only primary cultured cerebellar granule neurones resulted in significant apoptosis, but the presence of astrocytes largely prevented the effect. The supernatants of the stimulated astrocytes, especially those that contained the highest level of IL-17, achieved the best protection, and this effect could be blocked by anti-IL-17 antibodies. Protein IL-17 inhibited intracellular calcium increase and protected the neurones under inflammatory attack from apoptosis. IL-17, but not interferon (IFN)-, in the inflammatory media contributed to astrocyte secretion of IL-17, which depended on the Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway activation. The astrocytes that were treated with IL-17 alone or with prolonged treatment of the inflammatory media failed to produce sufficient levels of IL-17. Moreover, confirmatory data were obtained in vivo in a monophasic experimental autoimmune uveitis (EAU) in Lewis rats; in this preparation, the high-level IL-17-containing the cytokine milieu was demonstrated, along with IL-17 secretion by the resident neural cells. The antagonism of IL-17 at a late stage disturbed the disease resolution and resulted in significant neural apoptosis. Our data show a dynamic role of IL-17 in the maintenance of homeostasis and neuroprotection in active neuroinflammation.

分类号：

  • 相关文献

[1]Neuroprotection against hydrogen peroxide-induced toxicity by Dictyophora echinovolvata polysaccharide via inhibiting the mitochondria-dependent apoptotic pathway. Yu, Wen-Xuan,Dong, Xiao-Li,Lin, Chen-Qiang,Lin, Xin-Jian,Yu, Wen-Xuan,Dong, Xiao-Li,Yu, Wen-Xuan,Dong, Xiao-Li,Zhao, Qing.

[2]Autophagy Plays an Important Role in Anti-inflammatory Mechanisms Stimulated by Alpha7 Nicotinic Acetylcholine Receptor. Shao, Bo-Zong,Ke, Ping,Xu, Zhe-Qi,Cheng, Ming-He,Han, Bin-Ze,Su, Ding-Feng,Liu, Chong,Wei, Wei,Chen, Xiong-Wen. 2017

[3]Activating alpha 7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of beta-arrestin-1. Ke, Ping,Shao, Bo-Zong,Xu, Zhe-Qi,Liu, Chong,Ke, Ping,Chen, Xiong-Wen,Wei, Wei. 2017

作者其他论文 更多>>
  • Metabolite analysis of peach (Prunus persica L. Batsch) branches in response to freezing stress

    作者：Li, Y.;Wang, Y.;Wang, Z.;Liu, G.;Chang, R.;Chen, H.;Li, J.;Tian, Q.

    关键词：Freezing stress; Metabolic networks; Metabolism; Peach

  • First Report of Green Mold on Leaves of Phaseolus vulgaris Caused by Cladosporium tenuissimum in Liaoning, China

    作者：Gao, X. M.;Li, Y.;Yu, M.;Ao, J.;Liu, X. H.;Sun, Y. L.;Song, L. Q.;Chen, F.;Guo, L. L.;Yang, X. H.

    关键词：Cladosporium tenuissimum; green mold; kidney bean

  • The first intron of EIJ1 confers a specific response to wounding and herbivore stresses

    作者：Yin, M.;Liu, H.;Yin, M.;Liu, H.;Yin, M.;Liu, H.;Li, Y.;Li, Y.

    关键词：EIJ1; intron; plant stress response; wounding and herbivore stresses; wounding inducible

  • Polyphasic taxonomy clarifies the relationships between Butyriboletus and Exsudoporus , and new taxa and reports of Boletaceae from China

    作者：Wang, Y.;Yang, Xy;Liu, Yj;Rao, G.;Gui, Xy;Wang, L. Y.;Zhang, B.;Li, Y.;Wang, Y.;Li, Y.;Ma, Yh;Wu, G.;Wu, G.;Dai, D.;Chen, X.

    关键词：16 new taxa; basidiomycota; biogeography; evolution; long-distance dispersal; phylogeny

  • The 2024 Outline of Fungi and fungus-like taxa

    作者：Hyde, K. D.;Thiyagaraja, V;Kularathnage, N. D.;Li, Y. C.;Wang, Z. Y.;Zhao, Q.;Hyde, K. D.;Wijesinghe, S. N.;Armand, A.;Chethana, K. W. T.;Perera, R. H.;Phukhamsakda, C.;Wannasawang, N.;Asghari, R.;Aumentado, H. D. R.;Bera, I;Bhunjun, C. S.;Boonmee, S.;Bundhun, D.;Chaharmiri-Dokhaharani, S.;Gajanayake, A. J.;Gomdola, D.;Gunarathne, A.;He, S. C.;Htet, Z. H.;Jayawardena, R. S.;Karimi, O.;Khyaju, S.;Kularathnage, N. D.;Lestari, A. S.;Li, C.;Li, H.;Liao, C. F.;Linn, M. M.;Luangharn, T.;Luo, L.;Madagammana, A. D.;Mapook, A.;Meng, Q. F.;Mukhopadhyay, S.;Pathirana, L. S.;Pem, D.;Phonemany, M.;Phongeun, S.;Shu, Y. X.;Silva, V. S. H.;Su, H.;Sun, Y. R.;Sysouphanthong, P.;Tan, T. H.;Tang, X.;Thakshila, S. A. D.;Walker, A.;Wei, D. P.;Wu, N.;Xiong, Y. R.;Yang, H. D.;Yang, Y. H.;Yang, Y. Y.;Yu, F. M.;Yuan, L. L.;Zeng, M.;Zhang, J. Y.;Zhao, H. J.;Zhu, X. Y.;Hyde, K. D.;Noorabadi, M. T.;Chen, Y. P.;Manawasinghe, I. S.;Xu, B.;Yang, Y. H.;He, M. Q.;Johnston, P. R.;McKenzie, E. H. C.;Biketova, A. Y.;Biketova, A. Y.;Chethana, K. W. T.;Bhunjun, C. S.;Gomdola, D.;Htet, Z. H.;Jayawardena, R. S.;Li, H.;Liao, C. F.;Linn, M. M.;Luo, L.;Madagammana, A. D.;Meng, Q. F.;Rathnayaka, A. R.;Shu, Y. X.;Su, H.;Xiong, Y. R.;Yang, H. D.;Yang, Y. H.;Erdogdu, M.;Ge, Z. W.;Groenewald, J. Z.;Crous, P. W.;Groenewald, M.;Hernandez-Restrepo, M.;Houbraken, J.;Sandoval-Denis, M.;Hongsanan, S.;Khuna, S.;Kusan, I;Matocec, N.;Mesic, A.;Posta, A.;Tkalcec, Z.;Leontyev, D., V;Leontyev, D., V;Li, D. W.;Lin, C. G.;Liu, N. G.;Lu, Y. Z.;Tian, X. G.;Yang, Y.;Maharachchikumbura, S. S. N.;Tian, Q.;Chen, Y. P.;Dissanayake, A. J.;Liu, J. K.;Liu, J. W.;Madhushan, A.;Tian, W. H.;Zhang, S.;May, T. W.;Davoodian, N.;Piatek, M.;Czachura, P.;Darmostuk, V;Flakus, A.;Janik, P.;Ronikier, A.;Stryjak-Bogacka, M.;Worobiec, G.;Samarakoon, M. C.;Cheewankoon, R.;Chen, C.;Haituk, H.;Selcuk, F.;Ulukapi, M.;Senanayake, I. C.;Senanayake, I. C.;Tanney, J. B.;Vizzini, A.;Wanasinghe, D. N.;Dissanayake, A. J.;Wijayawardene, N. N.;Dai, D. Q.;Du, T. Y.;Jayasiri, S. C.;Karunarathna, S. C.;Liu, X. F.;Lu, L.;Tibpromma, S.;Xu, R. F.;Zhao, R. L.;Cao, B.;Chen, Q.;Li, J.;Liu, F.;Liu, S. L.;Wei, X.;Abdel-Wahab, M. A.;Abdollahzadeh, J.;Abeywickrama, P. D.;Abeywickrama, P. D.;Absalan, S.;Afshari, N.;Chaiwan, N.;Samaradiwakara, N. P.;Tennakoon, D. S.;Acharya, K.;Afshan, N. S.;Khalid, A. N.;Muhammad, U.;Najam Ul Sehar, A.;Naseer, A.;Niazi, A. R.;Sarwar, S.;Usman, M.;Afzalinia, S.;Ahmadpour, S. A.;Eisvand, P.;Mehrabi-Koushki, M.;Safi, A.;Akulov, O.;Alizadeh, A.;Alizadeh, M.;Al-Sadi, A. M.;Thamodini, G. K.;Alves, A.;Alves, V. C. S.;Alves-Silva, G.;Drechsler-Santos, E. R.;Antonin, V;Sevcikova, H.;Aouali, S.;Aptroot, A.;Apurillo, C. C. S.;Arias, R. M.;Heredia, G.;Asgari, B.;Zare, R.;Assis, D. M. A.;Barbosa, R. N.;da Silva, G. A.;da Silva, R. M. F.;da Silva Santos, A. C.;Diniz, A. G.;Gibertoni, T. B.;Lima, J. M. S.;Malosso, E.;Meiras-Ottoni, A. de;Mendes-Alvarenga, R. L.;Moura, J. C.;Santiago, A. L. C. M. A.;Souza-Motta, C. M.;Tiago, P., V;Assyov, B.;Denchev, C. M.;Denchev, T. T.;Atienza, V;Garrido-Benavent, I;Avasthi, S.;Azevedo, E.;Caeiro, M. F.;Azevedo, E.;Caeiro, M. F.;Bakhshi, M.;Druzhinina, I. S.;Bao, D. F.;Baral, H. O.;Barata, M.;Barata, M.;Barbosa, K. D.;Lima, J. L. R.;Nascimento, E. C. R.;Oliveira, N. V. L.;Queiroz, M. B.;Silva, H. F.;Barbosa, F. R.;Baroncelli, R.;Barreto, G. G.;Gusmao, L. F. P.;Baschien, C.;Schoutteten, N.;Bennett, R. M.;dela Cruz, T. E. E.;Bennett, R. M.;Bezerra, J. D. P.;Carvalho, T. G.;Bianchinotti, M., V;Bianchinotti, M., V;Blaszkowski, J.;Boekhout, T.;Bonito, G. M.;Boonyuen, N.;Luangsa-ard, J. J.;Bortnikov, F. M.;Fedosova, A. G.;Novozhilov, Y. K.;Zmitrovich, I., V;Bregant, C.;Linaldeddu, B. T.;Burgaud, G.;Buyck, B.;Caeiro, M. F.;Cabarroi-Hernandez, M.;Cortes-Perez, A.;Guzman-Davalos, L.;Ramirez-Cruz, V;Feng, Cai M.;Cai, L.;Feng, Cai M.;Calabon, M. S.;Calaca, F. J. S.;Calaca, F. J. S.;Calaca, F. J. S.;Callalli, M.;Callalli, M.;Camara, M. P. S.;Cano-Lira, J.;Garcia-Sanchez, D.;Gene, J.;Carlavilla, J. R.;Carvalho, A.;Carvalho, A.;Castaneda-Ruiz, R. F.;Catania, M. D., V;Salvador-Montoya, C. A.;Cazabonne, J.;Cazabonne, J.;Cedeno-Sanchez, M.;Stadler, M.;Chaiwan, N.;Haituk, H.;Chakraborty, N.;Chen, J.;Chinaglia, S.;Garzoli, L.;Marchese, P.;Coelho-Nascimento, C. C.;Coelho-Nascimento, C. C.;Coelho-Nascimento, C. C.;Menolli Jr, N.;Zabin, D. A.;Coleine, C.;Selbmann, L.;Zucconi, L.;Costa-Rezende, D. H.;Cortes-Perez, A.;Crouch, J. A.;Cruz, R. H. S. F.;Damm, U.;Daroodi, Z.;Mamarabadi, M.;Das, K.;Das, K.;Davydov, E. A.;da Silva, I. R.;Dai, Y. C.;Michiel, de Groot D.;De Lange, R.;Haelewaters, D.;Schoutteten, N.;De Kesel, A.;de Medeiros, E., V;de Souza, C. F. A.;de Souza, F. A.;Decock, C.;Delgado, G.;Denchev, C. M.;Denchev, T. T.;Deng, Y. L.;Dong, J. H.;Gu, Z. R.;Yang, X.;Yuan, Q.;Zhang, X. C.;Zhao, C. L.;Zhou, H. M.;Dentinger, B. T. M.;Dentinger, B. T. M.;Devadatha, B.;Devadatha, B.;Dianese, J. C.;Dima, B.;Doilom, M.;Dong, W.;Dong, Z. Y.;Li, Y.;Li, Y. X.;Liao, C. F.;Luo, M.;Dolatabadi, S.;Dubey, M. K.;Dutta, A. K.;Elliott, T. F.;Elshahed, M. S.;Vinzelj, J. M.;Youssef Noha, H.;Egidi, E.;Fan, L.;Fan, X.;Fan, X. L.;Ferro, L. O.;Fonseca, E. O.;Nascimento, S. S.;Oliveira Junior, I;Prazeres, J. F. S. A.;Fiuza, P. O.;Fryar, S. C.;Gabaldon, T.;Gabaldon, T.;Gabaldon, T.;Gabaldon, T.;Gannibal, P. B.;Gao, F.;Garcia-Sandoval, R.;Gasca-Pineda, J.;Gautam, A. K.;Ghobad-Nejhad, M.;Ghosh, A.;Giachini, A. J.;Gentekaki, E.;Gmoshinskiy, V., I;Goes-Neto, A.;Gorjon, S. P.;Goto, B. T.;Granados-Montero, M. M.;Granados-Montero, M. M.;Griffith, G. W.;Grossart, H-P;Grossart, H-P;Gueidan, C.;Gunaseelan, S.;Guo, S. L.;Gutierrez, A. C.;Haelewaters, D.;Halling, R. E.;Hosoya, T.;Hoog, S. D.;Horak, E.;Hou, C. L.;Huang, S. K.;Huang, W. J.;Hurdeal, V. G.;Hustad, V. P.;Inacio, C. A.;Jayalal, R. G. U.;Jeewon, R.;Jeronimo, G. H.;Jin, J.;Jones, E. B. G.;Joshi, Y.;Jurjevic, Z.;Justo, A.;Kakishima, M.;Kaliyaperumal, M.;Kang, G. P.;Kang, G. P.;Kang, J. C.;Karpov, S. A.;Karpov, S. A.;Kezo, K.;Khan, M. K.;Kirchmair, M.;Neuhauser, S.;Peintner, U.;Klawonn, I;Kraisitudomsook, N.;Kukwa, M.;Kumar, S.;Lachance, M. A.;Lado, C.;Latha, K. P. D.;Lee, H. B.;Leonardi, M.;Lestari, A. S.;Li, Q.;Lima, N. B.;Lin, L.;Liu, S.;Liu, S.;Liu, X. Y.;Longcore, J. E.;Lumbsch, H. T.;Luo, Z. L.;Ma, J.;Madrid, H.;Magurno, F.;Magyar, D.;Mahadevakumar, S.;Malysh, J. M.;Manfrino, R. G.;Manimohan, P.;Mao, N.;Marasinghe, D. S.;Mardones, M.;Mardones, M.;Marin-Felix, Y.;Marin-Felix, Y.;Masigol, H.;Mehrabi, M.;Melo, R. F. R.;Mendieta, S.;Meng, Q. F.;Menkis, A.;Miksik, M.;Miller, S. L.;Moncada, B.;Moncada, B.;Moncalvo, J. M.;Moncalvo, J. M.;Monteiro, J. S.;Monteiro, J. S.;Monteiro, M.;Mora-Montes, H. M.;Moroz, E. L.;Nagy, G. L.;Najafiniya, M.;Nanayakkara, C. M.;Neves, M. A.;Yong, Nie;Nilsson, R. H.;Nogueira, P. T. S.;Noordeloos, M.;Norphanphoun, C.;Nunez Otano, N.;Zapata, C., V;O'Donnell, R. P.;Oehl, F.;Oliveira, J. A.;Oliveira, P. H. F.;Orihara, T.;Oset, M.;Pang, K. L.;Pang, K. L.;Papp, V;Pereira, O. L.;Perez-Moreno, J.;Perez-Ortega, S.;Peter, G.;Pires-Zottarelli, C. L. A.;Quan, Y.;Quandt, C. A.;Radek, R.;Rahnama, K.;Raj, K. N. A.;Rajeshkumar, K. C.;Soumyadeep, Rajwar;AB, Ralaiveloarisoa;Rama, T.;Rambold, G.;Raza, M.;Ren, G. C.;Rinaldi, A. C.;Rivas-Ferreiro, M.;Robledo, G. L.;Rossi, W.;Rusevska, K.;Ryberg, M.;Salimi, F.;Samant, B.;Sanchez-Castro, I;Santos, A. C. D. S.;Santos, L. A. dos;Sarma, V. V.;Savchenko, A.;Savchenko, A.;Saxena, R. K.;Schoutteten, N.;Schoutteten, N.;Sharma, A.;Shen, H. W.;Shen, Y. M.;Silva-Filho, A. G. S.;Simmons, D. R.;Singh, R.;Sir, E. B.;Sir, E. B.;Sir, E. B.;Sohrabi, M.;de Souza, F. A.;Sri-indrasutdhi, V;Sruthi, O. P.;Stemler, J.;Stemler, J.;Feng, Cai M.;Stemler, J.;Stemler, J.;Stephenson, S. L.;Stoyneva-Gaertner, M. P.;Strassert, J. F. H.;Su, H.;Svantesson, S.;Takamatsu, S.;Tan, T. H.;Tan, T. H.;Tanaka, K.;Tang, C.;Taylor, J. E.;Taylor, P. W. J.;Thambugala, K. M.;Thilanga, D.;Thines, M.;Thines, M.;Tokarev, Y. S.;Tomsovsky, M.;Torruella, G.;Tsurykau, A.;Udayanga, D.;Untereiner, W. A.;Uzunov, B. A.;Vadthanarat, S.;Valenzuela, R.;Van den Wyngaert, S.;Van Vooren, N.;Velez, P.;Verma, R. K.;Verma, R. K.;Vieira, W. A. S.;Tang, A. M. C.;Walker, A. K.;Wang, Q. M.;Wang, Y.;Wang, X. Y.;Wang, Z. Y.;Wannathes, N.;Wartchow, F.;Weerakoon, G.;White, J. F.;Wijesundara, D. S. A.;Wisitrassameewong, K.;Wu, H. X.;Xiong, Y. R.;Xu, J. P.;Xu, R.;Xu, R. J.;Yadav, S.;Yakovchenko, L. S.;Yoshioka, R.;Yoshioka, R.;Yu, Z. F.;Zamora, J. C.;Zeng, X. Y.;Zhang, J. F.;Zhang, J. F.;Zhao, H.;Zvyagina, E.;Zvyagina, E.

    关键词：classes; classification; families; genera; orders; phyla

  • Transcriptome analysis reveals heat shock protein 70 (HSP70) induced by tembusu virus infection is associated with immune responses

    作者：Zhao, D.;Han, K.;Zhang, L.;Huang, X.;Liu, Q.;Yang, J.;Liu, Y.;Li, Y.;Wu, F.;Zhao, D.;Zhao, D.;Zhao, D.;Han, K.;Zhang, L.;Huang, X.;Liu, Q.;Yang, J.;Liu, Y.;Li, Y.;Wu, F.

    关键词：heat shock protein 70; innate immune response; tembusu virus; transcriptome analysis

  • Characterization and High Expression of a Novel Alkalinegh11 Xylanase in Pichia pastoris

    作者：Wang, Y.;Deng, Y. -D.;Zhang, W. H.;Gong, Z. -H.;Qian, C.;Peng, R. -H.;Yao, Q. -H.;Tian, Y. -S.;Han, H. -J.;Zhang, W. -Y.;Wang, Y.;Han, H. -J.

    关键词：alkali-tolerant; codon optimization; thermostability; xylanases

微信小程序