Synthesis and In Vitro Anticancer Activity of Novel 2-((3-thioureido)carbonyl)phenyl Acetate Derivatives

文献类型： 外文期刊

第一作者： Xiong, Lin

作者： Xiong, Lin;Gao, Ya-Qin;Niu, Chu-E;Wang, Hong-Bo;Li, Wei-Hong;Xiong, Lin;Gao, Ya-Qin;Niu, Chu-E;Wang, Hong-Bo;Li, Wei-Hong

作者机构：

关键词： Anticancer activity;Aspirin derivatives;Anti-leukemia activity;Synthesis;MTT;In vitro

期刊名称：LETTERS IN DRUG DESIGN & DISCOVERY （ 影响因子：1.15； 五年影响因子：0.994 ）

ISSN： 1570-1808

年卷期： 2014 年 11 卷 2 期

页码：

收录情况： SCI

摘要： Novel simplified Aspirin derivatives were developed, characterized by using IR, H-1 NMR, C-13 NMR and elemental analysis techniques and evaluated for anticancer activity in human cell lines. The results revealed that most of the compounds exhibited inhibitory effects of growth of cancer cell lines in vitro against T-acute lymphoblastic leukemia cell lines Molt-4, chronic myclogenous leukemia cell lines K-562, acute myelocytic leukemia cells lines HL-60, human breast cancer cell lines MCF-7, human hepatic carcinoma cell lines HepG-2 and human lung cancer cell lines A-549. It was observed that some of these compounds exhibited significant anticancer activity particularly 5i which had stronger antileukemia activity with IC50 values ranging from 11.12 to 19.25 mu mol.L-1 against 3 leukemia cells than control fluorouracil, so some of the compounds may constitute a novel class of anticancer medicines, which deserves further study.

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