Spectrum-Effect Relationship Between High Performance Liquid Chromatography Fingerprints and Anticoccidial Activities of a Compound Chinese Medicine

文献类型： 外文期刊

第一作者： Xiao Sui

作者： Xiao Sui;Fei Chen-zhong;Zhang Li-fang;Zheng Wen-li;Zhang Ke-yu;Xue Fei-qun

作者机构： Chinese Acad Agr Sci, Shanghai Vet Res Inst, Key Lab Vet Drug Safety Evaluat & Residues Res, Shanghai 200241, Peoples R China

关键词： herb medicine;fingerprint;anticoccidial index;spectrum-effect relationship

期刊名称：JOURNAL OF INTEGRATIVE AGRICULTURE （ 2020影响因子：2.848； 五年影响因子：2.979 ）

ISSN： 2095-3119

年卷期： 2014 年 13 卷 5 期

页码：

收录情况： SCI

摘要： Quality control and screening of active substances in traditional Chinese medicines have been performed using fingerprint analysis. The spectrum-effect relationship between chromatography fingerprints and efficacy of herbal drugs is considered as a potentially useful method for determining active ingredients in complex mixtures. The study was designed to develop a method for determining the bioactive components of a compound Chinese medicine called Tiefeng based on spectrum-effect relationships between high-performance liquid chromatography (HPLC) fingerprints and anticoccidial activities. Four peaks of the established HPLC fingerprint indicate the main bioactive components of this medicine. In addition, pharmacodynamic atlas was defined and used to assess the anticoccidial activity of Tiefeng from different sources for the first time. We found that the level of anticoccidial activity of Tiefeng was consistent with the degree of similarity between the pharmacodynamic atlas and chromatogram of any sample. Furthermore, effect of this medicine was related with the main active constituents, along with the origin and the harvesting time.

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