FSTL1 and TLR4 interact with PEDV structural proteins to promote virus adsorption to host cells

文献类型： 外文期刊

第一作者： Liu, Chunyun

作者： Liu, Chunyun;Kong, Ning;Qin, Wenzhen;Zhao, Wenli;Yang, Xinyu;Wang, Yahe;Cao, Xinyu;Liu, Tian;Liu, Yuchang;Sun, He;Tong, Wu;Yu, Hai;Zheng, Hao;Tong, Guangzhi;Shan, Tongling;Liu, Chunyun;Zhao, Wenli;Lan, Daoliang;Kong, Ning;Shan, Tongling;Liu, Hailong;Xie, Shengsong;Liu, Hailong;Xie, Shengsong;Zhang, Yu

作者机构：

关键词： FSTL1; TLR4; PEDV; structural proteins; virus adsorption

期刊名称：JOURNAL OF VIROLOGY （ 影响因子：3.8； 五年影响因子：3.9 ）

ISSN： 0022-538X

年卷期： 2025 年 99 卷 1 期

页码：

收录情况： SCI

摘要： Infection with porcine epidemic diarrhea virus (PEDV) results in enormous economic damage to the global swine industry. PEDV starts its life cycle by binding to the receptors of host cells and adsorbing onto the cellular surfaces. However, it is still unknown how PEDV adsorbs onto the surface of host cells and the mechanism beneath the interplay of host cell transmembrane protein with PEDV proteins. FSTL1, which is a secreted glycoprotein, participates in diverse pathological and physiological processes, including immune modulation and cell proliferation and differentiation. The transmembrane protein, TLR4, serves as a pattern recognition receptor recognizing a broad spectrum of pathogens, which exerts a crucial effect on the host immune system. In this study, we identified that FSTL1 promoted PEDV infection. Further studies demonstrated the interactive relationship between FSTL1 and PEDV structural proteins (N and S2). In addition, we also confirmed that TLR4 interacted with FSTL1 and PEDV N, S1, and S2 proteins on the cell surface. Moreover, FSTL1 promoted the interaction of TLR4 and PEDV and induced viral adsorption to host cells. This study offers explicit evidence that FSTL1 and TLR4 act as mediators for host cell adsorption of PEDV by interacting with PEDV N/S proteins.

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