Phase Separation: Orchestrating Biological Adaptations to Environmental Fluctuations

文献类型： 外文期刊

第一作者： Wang, Wenxiu

作者： Wang, Wenxiu;Su, Bodan;Wang, Jin;Wang, Wenxiu;Qi, Zhi;Yan, Chunxia;Han, Fangbing

作者机构：

关键词： phase separation; biomolecular condensates; weak interactions; stress resistance; environmental adaptability

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：4.9； 五年影响因子：5.7 ）

ISSN： 1661-6596

年卷期： 2025 年 26 卷 10 期

页码：

收录情况： SCI

摘要： Organisms have evolved various protective mechanisms to survive in complex and dynamic environments. Phase separation is a ubiquitous mechanism in plants, animals, and microorganisms. It facilitates the aggregation of biomolecules through weak interactions, forming membrane-less organelles that help organisms respond effectively to stress signals. These biomolecular condensates include DNA, RNA, and proteins. Proteins are categorized into scaffold and client proteins, whose coordinated actions ensure the compartmentalization of cellular signals, thereby regulating various biological processes. Studies indicate that, in response to stress, phase separation modulates gene expression, signal transduction, cytoskeleton dynamics, and protein homeostasis, ensuring the precise spatiotemporal control of cellular functions. These insights underscore the crucial role of phase separation in maintaining cellular integrity and adaptability.

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