Pseudorabies Virus Variant in Bartha-K61-Vaccinated Pigs, China, 2012

文献类型： 外文期刊

第一作者： An, Tong-Qing

作者： An, Tong-Qing;Peng, Jin-Mei;Tian, Zhi-Jun;Zhao, Hong-Yuan;Li, Na;Liu, Yi-Min;Chen, Jia-Zeng;Leng, Chao-Liang;Sun, Yan;Chang, Dan;Tong, Guang-Zhi;Tong, Guang-Zhi

作者机构：

期刊名称：EMERGING INFECTIOUS DISEASES （ 影响因子：6.883； 五年影响因子：7.463 ）

ISSN： 1080-6040

年卷期： 2013 年 19 卷 11 期

页码：

收录情况： SCI

摘要： The widely used pseudorabies virus (PRV) Bartha-K61 vaccine has played a key role in the eradication of PRV. Since late 2011, however, a disease characterized by neurologic symptoms and a high number of deaths among newborn piglets has occurred among Bartha-K61-vaccinated pigs on many farms in China. Clinical samples from pigs on 15 farms in 6 provinces were examined. The PRV gE gene was detectable by PCR in all samples, and sequence analysis of the gE gene showed that all isolates belonged to a relatively independent cluster and contained 2 amino acid insertions. A PRV (named HeN1) was isolated and caused transitional fever in pigs. In protection assays, Bartha-K61 vaccine provided 100% protection against lethal challenge with SC (a classical PRV) but only 50% protection against 4 challenges with strain HeN1. The findings suggest that Bartha-K61 vaccine does not provide effective protection against PRV HeN1 infection.

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