Synthesis and Biological Activities of 1,2,3-Thiadiazole Derivatives Containing 1,3,4-Thiadiazole Moiety

文献类型： 外文期刊

第一作者： Wang Shouxin

作者： Wang Shouxin;Wang Shouxin;Zuo Xiang;Fan Zhijin;Zhang Zhengcai;Zhang Jufang;Xiong Lixia;Fu Yifeng;Fang Zhen;Wu Qingjun;Zhang Youjun

作者机构：

关键词： 1,2,3-thiadiazole;1,3,4-thiadiazole;synthesis;fungicidal activity;insecticidal activity

期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：1.652； 五年影响因子：1.2 ）

ISSN： 0253-2786

年卷期： 2013 年 33 卷 11 期

页码：

收录情况： SCI

摘要： To find novel pesticide lead compounds with highly active bioactivity, 32 novel 1,2,3-thiadiazole derivatives containing 1,3,4-thiadiazole ring were designed and synthesized according to the principle of combination of bioactive substructures. All structures were confirmed by H-1 NMR, IR and HRMS. The fungicidal and insecticidal activities of these compounds were also evaluated. The bioassay results showed that some target compounds had good fungicidal activity and excellent insecticidal activities. Among them, compounds 5-3, 5-20 and 5-31 showed similar insecticidal activity against Plutella xylostella L. as compared with positive control chlorfluazuron at the same condition, compounds 5-6, 5-7, 5-10, 5-14 and 5-17 presented 100% insecticidal activity against Culex pipiens pollen at the concentration of 5 mu g/mL.

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