Design, Synthesis, Antifungal Activities and 3D-QSAR of New N,N '-Diacylhydrazines Containing 2,4-Dichlorophenoxy Moiety

文献类型： 外文期刊

第一作者： Sun, Na-Bo

作者： Sun, Na-Bo;Jin, Jian-Zhong;Shi, Yan-Xia;Li, Bao-Ju;Liu, Xing-Hai;Tan, Cheng-Xia;Weng, Jian-Quan;Ma, Yi

作者机构：

关键词： N;N-diacylhydrazines;antifungal activity;synthesis;three-dimensional quantitative structure-activity relationships (3D-QSAR)

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2013 年 14 卷 11 期

页码：

收录情况： SCI

摘要： A series of new N,N-diacylhydrazine derivatives were designed and synthesized. Their structures were verified by H-1-NMR, mass spectra (MS) and elemental analysis. The antifungal activities of these N,N-diacylhydrazines were evaluated. The bioassay results showed that most of these N,N-diacylhydrazines showed excellent antifungal activities against Cladosporium cucumerinum, Corynespora cassiicola, Sclerotinia sclerotiorum, Erysiphe cichoracearum, and Colletotrichum orbiculare in vivo. The half maximal effective concentration (EC50) of one of the compounds was also determined, and found to be comparable with a commercial drug. To further investigate the structure-activity relationship, comparative molecular field analysis (CoMFA) was performed on the basis of antifungal activity data. Both the steric and electronic field distributions of CoMFA are in good agreement in this study.

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