The crystal structure of HIV CRF07 B '/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat

文献类型: 外文期刊

第一作者: Du, Jiansen

作者: Du, Jiansen;Xue, Hailing;Ma, Jing;Liu, Fang;Qiao, Wentao;Liu, Xinqi;Zhou, Jianhua;Shao, Yiming;Shao, Yiming

作者机构:

关键词: HIV;gp41;Crystal structure;Membrane fusion;Heptad repeat

期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )

ISSN: 0042-6822

年卷期: 2013 年 446 卷 1-2 期

页码:

收录情况: SCI

摘要: HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 gp41 evolved more basic and hydrophilic residues on its helix bundle surface. Based on sequence alignment, a hyper-mutant cluster located in the middle of HR2 heptads repeat was identified. The mutational study of these residues revealed that this site is important in HIV mediated cell-cell fusion and plays critical roles in conformational changes during viral invasion. (C) 2013 Elsevier Inc. All rights reserved.

分类号:

  • 相关文献

[1]Antigenic properties of a transport-competent influenza HA/HIV Env chimeric protein. Ye, Ling,Sun, Yuliang,Lin, Jianguo,Bu, Zhigao,Wu, Qingyang,Jiang, Shibo,Steinhauer, David A.,Compans, Richard W.,Yang, Chinglai. 2006

[2]Structural and biochemical insights into the V/I505T mutation found in the EIAV gp45 vaccine strain. Du, Jiansen,Ma, Jing,Wang, Jianxin,Liu, Fang,Qiao, Wentao,Liu, Xinqi,Wang, Xuefeng,Qin, Yuyin,Zhu, Chunhui,Zhou, Jianhua,Shao, Yiming,Shao, Yiming. 2014

[3]Structural and functional characterization of EIAV gp45 fusion peptide proximal region and asparagine-rich layer. Duan, Liangwei,Du, Jiansen,Liu, Xinqi,Wang, Xuefeng,Zhou, Jianhua,Wang, Xiaojun.

[4]Rab3A is a new interacting partner of synaptotagmin I and may modulate synaptic membrane fusion through a competitive mechanism. Xie, Chunliang,Li, Jianglin,Guo, Tianyao,Yan, Yizhong,Tang, Cheng,Wang, Ying,Chen, Ping,Wang, Xianchun,Liang, Songping,Xie, Chunliang.

[5]Integrin v1 Modulation Affects Subtype B Avian Metapneumovirus Fusion Protein-mediated Cell-Cell Fusion and Virus Infection. Yun, Bing-Ling,Guan, Xiao-Lu,Liu, Yong-Zhen,Zhang, Yao,Wang, Yong-Qiang,Qi, Xiao-Le,Cui, Hong-Yu,Liu, Chang-Jun,Zhang, Yan-Ping,Gao, Hong-Lei,Gao, Li,Li, Kai,Gao, Yu-Long,Wang, Xiao-Mei,Wang, Xiao-Mei.

[6]Wikstroelide M potently inhibits HIV replication by targeting reverse transcriptase and integrase nuclear translocation. Zhang Xuan,Yang Liu-Meng,Chen Huan,Zheng Yong-Tang,Huang Sheng-Zhuo,Zhao You-Xing,Zhang Xuan,Zhang Xuan,Gu Wan-Gang,Wan David Chi-Cheong,Zheng Chang-Bo. 2014

[7]Prevalence of Cryptosporidium, microsporidia and Isospora infection in HIV-infected people: a global systematic review and meta-analysis. Wang, Ze-Dong,Zhu, Xing-Quan,Liu, Quan,Zhao, Yong-Kun,Liu, Quan,Liu, Huan-Huan,Li, Shuang,Zhang, Li. 2018

[8]Crystal Structure Analysis and the Identification of Distinctive Functional Regions of the Protein Elicitor Mohrip2. Wang, Meifang,Zeng, Hongmei,Qiu, Dewen,Duan, Liangwei,Liu, Xinqi. 2016

[9]SYNTHESIS AND STRUCTURE-ANTITUMOR ACTIVITY RELATIONSHIP OF SULFONYL 5-FLUOROURACIL DERIVATIVES. Chen, Fan,Zhao, Kejian,Hu, Maolin,Hou, Yong. 2010

[10]Synthesis, Crystal Structure and Antifungal Activity of 2-((2-Fluorobenzyl)thio)-5-(pyridin-4-yl)-1,3,4-oxadiazole. Sun Guo-Xiang,Zhai Zhi-Wen,Sun Zhao-Hui,Weng Jian-Quan,Tan Cheng-Xia,Liu Xing-Hai,Shi Yan-Xia,Li Bao-Ju. 2016

[11]Construction of cadmium(II) and zinc(II) coordination frameworks based on 3,5-bis(benzoimidazo-1-ly)pyridine and carboxylate acids: Synthesis, crystal structures and photoluminescent properties. Xu, Jiakun,Wang, Shuaiyu,Sun, Mi,Xu, Jiakun,Yan, Xingchen,Sun, Xiaochun,Yan, Xingchen. 2013

[12]Crystal structure of Bacillus thuringiensis Cry8Ea1: An insecticidal toxin toxic to underground pests, the larvae of Holotrichia parallela. Wei, Lei,Wu, Xiaoai,Rao, Zihe,Guo, Shuyuan,Guo, Shuyuan,Liu, Yanfeng,Xue, Jing,Wu, Hongfu,Song, Fuping,Zhang, Jie,Huang, Dafang. 2009

[13]Structural and biochemical insights into nucleotide-rhamnose synthase/epimerase-reductase from Arabidopsis thaliana. Han, Xiaodong,Qian, Lei,Liu, Xinqi,Qian, Lei,Han, Xiaodong,Zhang, Lianwen,Zhang, Lianwen. 2015

[14]Crystal structures and theoretical calculations of two peculiar compounds derived from 4-benzoyl-3-methyl-1-phenyl-2-pyrazolin-5-one. Yan, Xingchen,Wu, Xiaojing,Xu, Jiakun,Fan, Yuhua,Bi, Caifeng,Zhang, Xia,Zhang, Zhongyu,Yan, Xingchen,Xu, Jiakun. 2014

[15]Synthesis, Crystal Structures and Luminescent Properties of pH-Dependent Zn (II) Coordination Polymers. Xu, Jiakun,Sun, Mi,Xu, Jiakun,Fan, Yuhua,Bi, Caifeng,Sun, Xiaochun. 2012

[16]Green synthesis of gold nanoparticles using Citrus maxima peel extract and their catalytic/antibacterial activities. Yuan, Chun-Gang,Huo, Can,Gui, Bing,Cao, Wei-Ping. 2017

[17]Hydrothermal synthesis of five new coordination polymers based on benzophenone-2, 4'-dicarboxylic acid and N-donor spacers. Xu, Jiakun,Fan, Yuhua,Bi, Caifeng,Xu, Jiakun,Sun, Mi,Sun, Xiaochun.

[18]Zinc coordination polymers with rigid dicarboxylates and semirigid 3,5-bis(imidazole-1-yl) pyridine: syntheses, structural topologies, and luminescent properties. Xu, Jiakun,Ju, Caixia,Sheng, Jun,Wang, Fang,Sun, Mi,Sun, Xiaochun,Ju, Caixia.

[19]Crystal structure of 2-aminobenzothiazolinium nitrate and theoretical study of the amino-imino tautomerism of 2-aminobenzothiazole. Yan, Xingchen,Wu, Xiaojing,Xu, Jiakun,Fan, Yuhua,Bi, Caifeng,Zhang, Xia,Zhang, Zhongyu,Yan, Xingchen,Xu, Jiakun.

[20]Crystal structure of cyclic nucleotide-binding-like protein from Brucella abortus. He, Zheng,Gao, Yuan,Li, Xuemei,Zhang, Xuejun C.,He, Zheng,Dong, Jing,Ke, Yuehua,Chen, Zeliang.

作者其他论文 更多>>