The crystal structure of HIV CRF07 B '/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat
文献类型: 外文期刊
第一作者: Du, Jiansen
作者: Du, Jiansen;Xue, Hailing;Ma, Jing;Liu, Fang;Qiao, Wentao;Liu, Xinqi;Zhou, Jianhua;Shao, Yiming;Shao, Yiming
作者机构:
关键词: HIV;gp41;Crystal structure;Membrane fusion;Heptad repeat
期刊名称:VIROLOGY ( 影响因子:3.616; 五年影响因子:3.967 )
ISSN: 0042-6822
年卷期: 2013 年 446 卷 1-2 期
页码:
收录情况: SCI
摘要: HIV CRF07 B'/C is a strain circulating mainly in northwest region of China. The gp41 region of CRF07 is derived from a clade C virus. In order to compare the difference of CRF07 gp41 with that of typical clade B virus, we solved the crystal structure of the core region of CRF07 gp41. Compared with clade B gp41, CRF07 gp41 evolved more basic and hydrophilic residues on its helix bundle surface. Based on sequence alignment, a hyper-mutant cluster located in the middle of HR2 heptads repeat was identified. The mutational study of these residues revealed that this site is important in HIV mediated cell-cell fusion and plays critical roles in conformational changes during viral invasion. (C) 2013 Elsevier Inc. All rights reserved.
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