Vaccines against Toxoplasma gondii: new developments and perspectives

文献类型： 外文期刊

第一作者： Zhang, Nian-Zhang

作者： Zhang, Nian-Zhang;Chen, Jia;Wang, Meng;Zhu, Xing-Quan;Petersen, Eskild;Zhu, Xing-Quan

作者机构：

关键词： cat;food animal;mice;Toxoplasma gondii;toxoplasmosis;vaccines

期刊名称：EXPERT REVIEW OF VACCINES （ 影响因子：5.217； 五年影响因子：5.106 ）

ISSN： 1476-0584

年卷期： 2013 年 12 卷 11 期

页码：

收录情况： SCI

摘要： Toxoplasmosis caused by the protozoan Toxoplasma gondii is a major public health problem, infecting one-third of the world human beings, and leads to abortion in domestic animals. A vaccine strategy would be an ideal tool for improving disease control. Many efforts have been made to develop vaccines against T. gondii to reduce oocyst shedding in cats and tissue cyst formation in mammals over the last 20 years, but only a live-attenuated vaccine based on the S48 strain has been licensed for veterinary use. Here, the authors review the recent development of T. gondii vaccines in cats, food-producing animals and mice, and present its future perspectives. However, a single or only a few antigen candidates revealed by various experimental studies are limited by only eliciting partial protective immunity against T. gondii. Future studies of T. gondii vaccines should include as many CTL epitopes as the live attenuated vaccines.

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