The transcription cofactor FgSwi6 plays a role in growth and development, carbendazim sensitivity, cellulose utilization, lithium tolerance, deoxynivalenol production and virulence in the filamentous fungus Fusarium graminearum

文献类型: 外文期刊

第一作者: Jiang, Linghuo

作者: Jiang, Linghuo;Fan, Feiyu;Qiu, Dewen

作者机构:

关键词: SWI6;Growth;Carbendazim;Cellulose;Lithium;Virulence

期刊名称:FUNGAL GENETICS AND BIOLOGY ( 影响因子:3.495; 五年影响因子:3.831 )

ISSN: 1087-1845

年卷期: 2013 年 58-59 卷

页码:

收录情况: SCI

摘要: Fusarium head blight (FHB) is a worldwide devastating disease of wheat, barley and other small grain cereals and caused primarily by Fusarium graminearum. Carbendazim (MBC) is one of the fungicides widely used to control FHB in China. In the present study, we have identified the F. graminearum locus FGSG_04220 as the sequence homolog for Saccharomyces cerevisiae ScSWI6, named FgSWI6 hereafter. Deletion of FgSWI6 causes mycelium of F. graminearum become sensitive to MBC in liquid medium. In addition, deletion of FgSWI6 reduces mycelial growth as well as production and development of conidia. F. graminearum cells lacking FgSWI6 show reduced production efficiency and sizes of perithecia as well as a defect in the production of ascus and ascospore. FgSWI6 is required for the cellulose utilization, lithium tolerance and deoxynivalenol (DON) production of this pathogen. Furthermore, deletion of FgSWI6 significantly attenuates the virulence of F. graminearum on wheat. Therefore, FgSwi6p plays an important role in growth and development of the economically important fungal pathogen F. graminearum as well as its resistance to MBC. (C) 2013 Elsevier Inc. All rights reserved.

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