kappa-Selenocarrageenan prevents microcystin-LR-induced hepatotoxicity in BALB/c mice

文献类型： 外文期刊

第一作者： Wang, Jing

作者： Wang, Jing;Yu, Shouyi;Jiao, Shouhai;Du, Yuguo;Jiao, Shouhai;Lv, Xiaowen;Ma, Min

作者机构：

关键词： kappa-Selenocarrageenan;Microcystin-LR;Oxidative damage;Mitochondrial dysfunction;Endoplasmic reticulum stress

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2013 年 59 卷

页码：

收录情况： SCI

摘要： Microcystins (MCs) are a family of cyclic heptapeptides that are produced by blooming algae Microcystis. MCs have been implicated in the development of liver cancer, necrosis and even intrahepatic bleeding. Effective prophylactic approaches and complete removal of MCs are urgently needed. Accumulating evidence suggests that microcystin-LR (MC-LR)-induced damage is accompanied by oxidative stress. Supplementation of Se can enhance resistance to oxidative stress. Therefore, in the present study, we investigated the protective effects of kappa-Selenocarrageenan (Se-Car), a kind of organic Se compound, in Balb/c mice exposed to MC-LR. Our results proved that Se-Car could significantly ameliorate the hepatic damage induced by MC-LR, including serum markers of liver dysfunction, oxidative damages and histological alterations. Furthermore, Se-Car could significantly alleviate the up-regulation of the molecular targets indicating mitochondrial dysfunction and endoplasmic reticulum stress induced by MC-LR. In conclusion, Se-Car showed clear protection against toxicity induced by MC-LR. Thus, Se-Car could be useful as a new category of anti-MC-LR toxicity reagent. (c) 2013 Elsevier Ltd. All rights reserved.

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