Evaluation of protective effect of pVAX-TgMIC13 plasmid against acute and chronic Toxoplasma gondii infection in a murine model

文献类型： 外文期刊

第一作者： Yuan, Zi-Guo

作者： Yuan, Zi-Guo;Ren, Di;Zhou, Dong-Hui;Zhou, Yang;Zhu, Xing-Quan;Yuan, Zi-Guo;Ren, Di;Zhang, Xiu-Xiang;Li, Xiu-Zhen;Petersen, Eskild;Petersen, Eskild;Yang, Gui-Lian;Zhu, Xing-Quan

作者机构：

关键词： Toxoplasma gondii;Toxoplasmosis;Micronemal protein 13;pVAX-TgMIC13;Protective immunity;Vaccine

期刊名称：VACCINE （ 影响因子：3.641； 五年影响因子：3.816 ）

ISSN： 0264-410X

年卷期： 2013 年 31 卷 31 期

页码：

收录情况： SCI

摘要： Toxoplasma gondii is a significant zoonotic parasite which can cause congenital infection and abortion in warm-blooded animals and humans. Microneme protein 13 (MIC13) plays an important role in attachment and penetration of the host cell by T. gondii. In this study, a DNA vaccine expressing mic13 of T. gondii was constructed and its protective efficacy was evaluated in Kunming L615(H2k) mice. Immunization with pVAX-TgMIC13 induced a strong immune responses demonstrated by significant lymphocyte proliferation, cytokine production and antibody responses. Immunized mice showed increased survival time (21.3 +/- 11.3 days) and reduced number of cysts in brain of mice (57.14%) after challenge with tachyzoites of the virulent T. gondii RH strain and cysts of the T. gondii PRU strain, respectively, demonstrating that T. gondii MIC13 is a potential vaccine candidate, worth being included in future vaccine development against acute and chronic T. gondii infection. (C) 2013 Elsevier Ltd. All rights reserved.

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