Synthesis, Characterization, and Antibacterial Activity of Cross-Linked Chitosan-Glutaraldehyde

文献类型： 外文期刊

第一作者： Li, Bin

作者： Li, Bin;Shan, Chang-Lin;Zhou, Qing;Ibrahim, Muhammad;Xie, Guan-Lin;Li, Bin;Wang, Yang-Li;Sun, Guo-Chang;Fang, Yuan;Xu, Fei;Han, Li-Rong;Guo, Long-Biao

作者机构：

关键词： antibacterial activity;characterization;chitosan;cross-link;glutaraldehyde

期刊名称：MARINE DRUGS （ 影响因子：5.118； 五年影响因子：5.951 ）

ISSN： 1660-3397

年卷期： 2013 年 11 卷 5 期

页码：

收录情况： SCI

摘要： This present study deals with synthesis, characterization and antibacterial activity of cross-linked chitosan-glutaraldehyde. Results from this study indicated that cross-linked chitosan-glutaraldehyde markedly inhibited the growth of antibiotic-resistant Burkholderia cepacia complex regardless of bacterial species and incubation time while bacterial growth was unaffected by solid chitosan. Furthermore, high temperature treated cross-linked chitosan-glutaraldehyde showed strong antibacterial activity against the selected strain 0901 although the inhibitory effects varied with different temperatures. In addition, physical-chemical and structural characterization revealed that the cross-linking of chitosan with glutaraldehyde resulted in a rougher surface morphology, a characteristic Fourier transform infrared (FTIR) band at 1559 cm(-1), a specific X-ray diffraction peak centered at 2 theta = 15 degrees, a lower contents of carbon, hydrogen and nitrogen, and a higher stability of glucose units compared to chitosan based on scanning electron microscopic observation, FTIR spectra, X-ray diffraction pattern, as well as elemental and thermo gravimetric analysis. Overall, this study indicated that cross-linked chitosan-glutaraldehyde is promising to be developed as a new antibacterial drug.

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