Early life dynamics of ARG and MGE associated with intestinal virome in neonatal piglets

文献类型： 外文期刊

第一作者： Wu, Ruiting

作者： Wu, Ruiting;Cao, Ze;Chen, Wei;Sun, Yuan;Li, Qianniu;Mi, Jiandui;Liao, Xindi;Lan, Tian;Ma, Jingyun;Wu, Ruiting;Cao, Ze;Chen, Wei;Sun, Yuan;Li, Qianniu;Mi, Jiandui;Liao, Xindi;Lan, Tian;Ma, Jingyun;Wu, Ruiting;Cao, Ze;Chen, Wei;Sun, Yuan;Li, Qianniu;Mi, Jiandui;Liao, Xindi;Lan, Tian;Ma, Jingyun;Feng, Yaoyu;Jiang, Yiming;Deng, Li;Jiang, Yiming;Deng, Li;Ma, Jingyun

作者机构：

关键词： Neonatal piglets; Intestinal virome; ARG; MGE; Multidrug resistance

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.3； 五年影响因子：3.5 ）

ISSN： 0378-1135

年卷期： 2022 年 274 卷

页码：

收录情况： SCI

摘要： The pre-and post-weaning stages for piglets are critical periods for the maturation of intestinal functions and contamination with antibiotic resistant bacterial pathogens will threaten their intestinal health. The presence of bacteriophage can also alter bacterial populations in the intestine but whether transmission of antibiotic resis-tance genes (ARG) is affected by phage during maturation of the neonatal piglet intestine is not known. We therefore identified the intestinal virome along with ARGs and mobile genetic elements (MGE) from piglet fecal samples collected from 3 to 28 days representing the different growth stages. We found wide fluctuations for the intestinal virome of weaning piglets and most virus -related antibiotic resistance was derived from temperate phage suggesting a reservoir of multidrug resistance was present in the neonatal porcine gut. Our results provide a comprehensive understanding of ARGs associated with the intestinal virome that therefore represents a po-tential risk for horizontal ARG transfer to pathogenic bacteria.

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