Adjuvant effects of interleukin-18 in DNA vaccination against infectious bursal disease virus in chickens

文献类型: 外文期刊

第一作者: Li, Kai

作者: Li, Kai;Gao, Honglei;Gao, Li;Qi, Xiaole;Gao, Yulong;Qin, Liting;Wang, Yongqiang;Wang, Xiaomei

作者机构:

关键词: Infectious bursal disease virus;DNA vaccine;Chicken interleukin-18;Adjuvant

期刊名称:VACCINE ( 影响因子:3.641; 五年影响因子:3.816 )

ISSN: 0264-410X

年卷期: 2013 年 31 卷 14 期

页码:

收录情况: SCI

摘要: Interleukin-18 (IL-18) is an important cytokine with multiple functions in innate and acquired immunity. In this study, chicken IL-18 was evaluated for its adjuvant effects on the protective immunity of a DNA vaccine carrying the VP243 gene of IBDV. Groups of 14-day-old SPF chickens were given twice at 2-week intervals with 100 mu g of the plasmid DNA vaccine pCAGVP243, pCAGVP243-IL-18 and the blank vector pCAGGS, respectively, and challenged with vvIBDV (HLJ0504 strain) 2 weeks later. Chickens immunized with plasmid pCAGVP243-IL-18 carrying both VP243 and IL-18 genes induced significantly higher levels of antibodies, lymphocyte proliferation responses and of the cytokines IL-4 and IFN-gamma, than those injected with pCAGVP243 encoding the VP243 gene alone. Furthermore, pCAGVP243-IL-18 provided higher protection (93%) against vvIBDV challenge in chickens than pCAGVP243 (60%), as evidenced by the absence of clinical signs, mortality, and bursal atrophy. These results indicated that the cytokine IL-18 could enhance the immune responses and protection efficacy of DNA vaccine against IBDV infection in chickens, highlighting the potential value of chicken IL-18 as an adjuvant in the prevention of vvIBDV infection. (C) 2013 Published by Elsevier Ltd.

分类号:

  • 相关文献

[1]Effects of different cytokines on immune responses of rainbow trout in a virus DNA vaccination model. Cao, Yongsheng,Xu, Liming,Li, Shaowu,Wang, Di,Zhao, Jingzhuang,Liu, Hongbai,Lu, Tongyan,Cao, Yongsheng,Zhang, Qiya,Feng, Jian. 2017

[2]The swine CD81 enhances E2-based DNA vaccination against classical swine fever. Li, Wenliang,Zhou, Bin,Liu, Xia,Yang, Leilei,Zhang, Wenwen,Jiang, Jieyuan,Zhou, Bin.

[3]DNA prime-protein boost vaccination enhances protective immunity against infectious bursal disease virus in chickens. Gao, Honglei,Li, Kai,Gao, Li,Qi, Xiaole,Gao, Yulong,Qin, Liting,Wang, Yongqiang,Wang, Xiaomei.

[4]Codon optimization and woodchuck hepatitis virus posttranscriptional regulatory element enhance the immune responses of DNA vaccines against infectious bursal disease virus in chickens. Li, Kai,Gao, Li,Gao, Honglei,Qi, Xiaole,Gao, Yulong,Qin, Liting,Wang, Yongqiang,Wang, Xiaomei.

[5]An inactivated gE-deleted pseudorabies vaccine provides complete clinical protection and reduces virus shedding against challenge by a Chinese pseudorabies variant. Wang, Jichun,Guo, Rongli,Qiao, Yongfeng,Xu, Mengwei,Wang, Zhisheng,Liu, Yamei,Gu, Yiqi,Liu, Chang,Hou, Jibo,Gu, Yiqi,Liu, Chang,Wang, Jichun,Guo, Rongli,Qiao, Yongfeng,Xu, Mengwei,Wang, Zhisheng,Liu, Yamei,Hou, Jibo. 2016

[6]CTA1: Purified and display onto gram-positive enhancer matrix (GEM) particles as mucosal adjuvant. Zhang, Yuanpeng,Yu, Xiaoming,Hou, Liting,Chen, Jin,Li, Pengcheng,Qiao, Xuwen,Zheng, Qisheng,Hou, Jibo,Zhang, Yuanpeng,Yu, Xiaoming,Hou, Liting,Chen, Jin,Li, Pengcheng,Qiao, Xuwen,Zheng, Qisheng,Hou, Jibo,Zhang, Yuanpeng,Yu, Xiaoming,Hou, Liting,Chen, Jin,Li, Pengcheng,Qiao, Xuwen,Zheng, Qisheng,Hou, Jibo. 2018

[7]Adjuvant Effect of Quillaja saponaria Saponin (QSS) on Protective Efficacy and IgM Generation in Turbot (Scophthalmus maximus) upon Immersion Vaccination. Wang, Yujuan,Wang, Xiuhua,Huang, Jie,Wang, Xiuhua,Huang, Jie,Li, Jun,Li, Jun,Li, Jun. 2016

[8]Lycium barbarum polysaccharides as an adjuvant for recombinant vaccine through enhancement of humoral immunity by activating Tfh cells. Su, Chun-xia,Feng-Wang,Zheng, Jie,Ling-Huang,Wang, Ning-ping,Duan, Xiang-guo,Duan, Xiang-guo,Duan, Xiang-guo,Liang, Li-jun,Fu, Xue-Yan,Yan, Ya-mei. 2014

[9]Enhancement of immune responses to Newcastle disease vaccine by a supplement of extract of Momordica cochinchinensis (Lour.) Spreng. seeds. Xiao, C.,Hu, S.,Xiao, C.,Bao, G.. 2009

[10]Salidroside liposome formulation enhances the activity of dendritic cells and immune responses. Zhao, Xiaojuan,Tao, Yang,Huang, Yee,Wang, Deyun,Hu, Yuanliang,Liu, Jiaguo,Wu, Yi,Yu, Yun,Liu, Cui,Zhao, Xiaojuan,Lu, Yu. 2013

[11]Characterization of droplet impact and deposit formation on leaf surfaces. Dong, Xiang,Yang, Xuejun,Zhu, Heping.

[12]Graphene Oxides Decorated with Carnosine as an Adjuvant To Modulate Innate Immune and Improve Adaptive Immunity in Vivo. Meng, Chunchun,Li, Chuanfeng,Chen, Zongyan,Qiu, Xusheng,Ding, Chan,Liu, Guangqing,Zhi, Xiao,Li, Chao,Chen, Di,Cui, Daxiang,Ding, Chan,Liu, Guangqing,Ma, Lijun,Lu, Hongmin.

[13]Improved neutralising antibody response against foot-and-mouth-disease virus in mice inoculated with a multi-epitope peptide vaccine using polyinosinic and poly-cytidylic acid as an adjuvant. Cao, Yimei,Lu, Zengjun,Li, Pinghua,Sun, Pu,Fu, Yuanfang,Bai, Xingwen,Bao, Huifang,Chen, Yingli,Li, Dong,Liu, Zaixin. 2012

[14]SjHSP70, a recombinant Schistosoma japonicum heat shock protein 70, is immunostimulatory and induces protective immunity against cercarial challenge in mice. Duan, Ming Ming,Xu, Rui Min,Yuan, Chun Xiu,Li, Yun Yan,Liu, Qun,Cheng, Guo Feng,Lin, Jiao-Jiao,Feng, Xin Gang,Li, Yun Yan,Liu, Qun,Lin, Jiao-Jiao.

[15]Recent advances in developing vaccines against Toxoplasma gondii: an update. Zhang, Nian-Zhang,Wang, Meng,Xu, Ying,Zhu, Xing-Quan,Xu, Ying,Petersen, Eskild. 2015

[16]Marburg virus-like particles by co-expression of glycoprotein and matrix protein in insect cells induces immune responses in mice. Gai, Weiwei,Zhang, Weijiao,Qiu, Boning,Gai, Weiwei,Wang, Hualei,Zhao, Yongkun,Wang, Qi,Zhang, Weijiao,Feng, Na,Qiu, Boning,Chi, Hang,Li, Nan,Wang, Tiecheng,Gao, Yuwei,Yang, Songtao,Xia, Xianzhu,Zheng, Xuexing,Wang, Chong,Wang, Qi,Wong, Gary,Shan, Junjie,Shan, Junjie,Yang, Songtao,Xia, Xianzhu. 2017

[17]Immunoenhancement with flagellin as an adjuvant to whole-killed rabies vaccine in mice. Xiao, Xing-xing,Zhang, Yun,Liu, Ji-xing,Wei, Qiao-lin,Yin, Xiang-ping.

[18]Protective efficacy evaluation induced by recombinant protein LHD-Sj23-GST of Schistosoma japonicum emulsified with three different adjuvants. Zhu, Z.,Fu, Z.,Zhang, M.,Han, Y.,Hong, Y.,Li, D.,Zhao, Z.,Shi, Y.,Lin, J.,Zhu, Z.,Han, Y.,Hong, Y.,Li, X..

[19]Effect of different adjuvant formulations on the immunogenicity and protective effect of a live Mycoplasma hyopneumoniae vaccine after intramuscular inoculation. Wang, Chunlai,Xie, Fang,Xiong, Qiyan,Wei, Yanna,Xie, Haidong,Feng, Zhixin,Gan, Yuan,Liu, Maojun,Bai, Fangfang,Shao, Guoqing.

[20]Antigen-Sparing and Enhanced Efficacy of Multivalent Vaccines Adjuvanted with Immunopotentiators in Chickens. Wu, Peipei,Lu, Jihu,Feng, Lei,Zhang, Xuehua,Mei, Mei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Feng, Lei,Zhang, Xuehua,Mei, Mei,Hou, Jibo,Tang, Yinghua,Wu, Peipei,Lu, Jihu,Feng, Lei,Zhang, Xuehua,Mei, Mei,Hou, Jibo,Liu, Xiufan,Tang, Yinghua,Wu, Hongzhuan,Liu, Xiufan. 2017

作者其他论文 更多>>