ADAM17 cleaves CD16b (Fc gamma RIIIb) in human neutrophils

文献类型： 外文期刊

第一作者： Wang, Yue

作者： Wang, Yue;Wu, Jianming;Bahaie, Nooshin S.;Long, Chunmei;Walcheck, Bruce;Wang, Yue;Newton, Robert

作者机构：

关键词： Neutrophil;Metalloprotease;ADAM17;Apoptosis;Fc receptor

期刊名称：BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH （ 影响因子：4.739； 五年影响因子：6.121 ）

ISSN： 0167-4889

年卷期： 2013 年 1833 卷 3 期

页码：

收录情况： SCI

摘要： CD16b (Fc gamma RIIIb) is exclusively expressed by human neutrophils and binds IgG in immune complexes. Cell surface CD16b undergoes efficient ectodomain shedding upon neutrophil activation and apoptosis. Indeed, soluble CD16b is present at high levels in the plasma of healthy individuals, which appears to be maintained by the daily turnover of apoptotic neutrophils. At this time, the principal protease responsible for CD16b shedding is not known. We show that CD16b plasma levels were significantly decreased in patients administered a selective inhibitor targeting the metalloproteases ADAM10 and ADAM17. Additional analysis with inhibitors selective for ADAM10 or ADAM17 revealed that only inhibition of ADAM 17 significantly blocked the cleavage of CD16b following neutrophil activation and apoptosis. CD16b shedding by ADAM17 was further demonstrated using a unique ADAM17 function-blocking mAb and a cell-based ADAM17 reconstitution assay. Unlike human CD16, however, mouse CD16 did not undergo, efficient ectodomain shedding upon neutrophil stimulation or apoptosis, indicating that this mechanism cannot be modeled in normal mice. Taken together, our findings are the first to directly demonstrate that ADAM17 cleaves CD16 in human leukocytes. (c) 2012 Elsevier B.V. All rights reserved.

分类号：

  • 相关文献

[1]Production of porcine TNF alpha by ADAM17-mediated cleavage negatively regulates porcine reproductive and respiratory syndrome virus infection. Li, Ren,Guo, Longjun,Gu, Weihong,Luo, Xiaolei,Zhang, Jian,Xu, Yunfei,Tian, Zhijun,Feng, Li,Wang, Yue.

[2]Characterization and ligand specificity of sheep IgG2 receptor. Zhang, Gaiping,Qiao, Songlin,Zhang, Gaiping,Yang, Suzhen,Qiao, Songlin,Yang, Yanyan,Liu, Yunchao,Zhang, Gaiping,Xi, Jun,Zhang, Hong,Hao, Huifang,Tian, Xiaohui,Yang, Suzhen,Deng, Ruiguang. 2009

[3]Cloning and characterization of ovine immunoglobulin G Fc receptor III (Fc gamma RIII). Qiao, Song Lin,Chen, Yumei,Yang, Suzhen,Deng, Ruiguang,Zhang, Gaiping,Liu, Yunchao,Chang, Junbiao,Wang, Aiping,Chang, Junbiao,Chen, Yumei. 2011

[4]Diversification and evolution of the avirulence gene AVR-Pita1 in field isolates of Magnaporthe oryzae. Dai, Yuntao,Jia, Yulin,Dai, Yuntao,Correll, James,Wang, Xueyan,Wang, Yanli. 2010

[5]Identification of a Proteolytic Bacterium, HW08, and Characterization of Its Extracellular Cold-Active Alkaline Metalloprotease Ps5. Yang, Chengye,Wang, Fang,Hao, Jianhua,Sun, Mi,Yang, Chengye,Zhang, Kai,Yuan, Na.

[6]Affinity purification of metalloprotease from marine bacterium using immobilized metal affinity chromatography. Li, Shangyong,Wang, Linna,Yang, Juan,Bao, Jing,Liu, Junzhong,Hao, Jianhua,Sun, Mi,Li, Shangyong,Wang, Linna,Yang, Juan,Bao, Jing,Liu, Junzhong,Hao, Jianhua,Sun, Mi,Li, Shangyong,Wang, Linna,Yang, Juan,Bao, Jing,Liu, Junzhong,Hao, Jianhua,Sun, Mi,Lin, Shengxiang.

[7]The Caspase Pathway of Linoelaidic Acid (9t, 12t-C18:2)-Induced Apoptosis in Human Umbilical Vein Endothelial Cells. Bin, Qiu,Rao, Huan,Hu, Jiang-Ning,Liu, Rong,Fan, Ya-Wei,Li, Jing,Deng, Ze-Yuan,Zhong, Xianfeng,Bin, Qiu,Du, Fang-Ling. 2013

[8]Detection of DNA ladder during cotyledon senescence in cotton. Q.E. XIE,I.D. LIU,S.X. YU,R.F. WANG,Z.X. FAN,Y.G. WANG,F.F. SHEN.

[9]Effects of species and cellular activity of oviductal epithelial cells on their dialogue with co-cultured mouse embryos. Tan, Xiu-Wen,Ma, Suo-Feng,Yu, Jian-Ning,Zhang, Xia,Lan, Guo-Cheng,Liu, Xin-Yong,Han, Zheng-Bin,Tan, Jing-He. 2007

[10]Oxidative Stress-Mediated Cytotoxicity of Cadmium in Chicken Splenic Lymphocytes. Li, Jin-Long,Tang, Zhao-Xin,Li, Jin-Long,Li, Shu,Xu, Shi-Wen,Li, Hui-Xin,Wang, Xiao-Long. 2010

[11]Heat stress inhibits proliferation, promotes growth, and induces apoptosis in cultured Lantang swine skeletal muscle satellite cells. Gao, Chun-qi,Zhao, Yin-ling,Sui, Wei-guo,Yan, Hui-chao,Wang, Xiu-qi,Li, Hai-chang. 2015

[12]Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials. Cui, Jianghu,Yang, Yunhua,Zheng, Mingtao,Liu, Yingliang,Xiao, Yong,Lei, Bingfu,Chen, Wei. 2014

[13]Mitophagy promotes replication of oncolytic Newcastle disease virus by blocking intrinsic apoptosis in lung cancer cells. Meng, Gang,Xia, Mao,Wang, Diancheng,Chen, Aiping,Wang, Hongwei,Yu, Decai,Wei, Jiwu,Yu, Decai,Wei, Jiwu,Wang, Yongshan. 2014

[14]Induction of apoptosis in the SW620 colon carcinoma cell line by triterpene-enriched extracts from Ganoderma lucidum through activation of caspase-3. Ji, Zhe,Tang, Qingju,Hao, Ruixa,Zhang, Jinsong,Ji, Zhe,Pan, Yingje. 2011

[15]Molecular characterization of SjBIRP, another apoptosis inhibitor, from Schistosoma japonicum. Dao, Jinwei,Zhu, Lihui,Luo, Rong,Hu, Chao,Wang, Yuqing,Li, Hao,Lu, Ke,Liu, Jinming,Lin, Jiaojiao,Cheng, Guofeng,Dao, Jinwei,Cheng, Guofeng. 2014

[16]Inhibition of p38 mitogen-activated protein kinase phosphorylation decreases H2O2-induced apoptosis in human lens epithelial cells. Bai, Jie,Zheng, Yi,Dong, Li,Liu, Ping,Cai, Xuehui,Wang, Gang. 2015

[17]Sperm pretreatment with glutathione improves IVF embryos development through increasing the viability and antioxidative capacity of sex-sorted and unsorted bull semen. Hu Ting-xi,Wang Zong-li,Hu Ting-xi,Zhu Hua-bin,Sun Wei-jun,Hao Hai-sheng,Zhao Xue-ming,Du Wei-hua. 2016

[18]Resveratrol induces apoptosis and inhibits adipogenesis by stimulating the SIRT1-AMPK alpha-FOXO1 signalling pathway in bovine intramuscular adipocytes. Liu, Xiaomu,Zhao, Hongbo,Jin, Qing,You, Wei,Cheng, Haijian,Liu, Yifan,Song, Enliang,Liu, Guifen,Tan, Xiuwen,Zhang, Xianglun,Wan, Fachun,Liu, Xiaomu,Zhao, Hongbo,Jin, Qing,You, Wei,Cheng, Haijian,Liu, Yifan,Song, Enliang,Liu, Guifen,Tan, Xiuwen,Zhang, Xianglun,Wan, Fachun. 2018

[19]BMP15 Prevents Cumulus Cell Apoptosis Through CCL2 and FBN1 in Porcine Ovaries. Zhai, Bo,Liu, Huiyu,Dai, Lisheng,Gao, Yan,Li, Changhong,Zhang, Lianjiang,Yu, Xianfeng,Zhang, Jiabao,Li, Xu. 2013

[20]Protective Effects of Quercetin on Cadmium-induced Cytotoxicity in Primary Cultures of Rat Proximal Tubular Cells. Wang Lin,Liu Gang,Wang Zhen Yong,Lin Shu Qian,He Yuan Long. 2013

作者其他论文 更多>>

微信小程序