Association of novel single-nucleotide polymorphisms of the vascular endothelial growth factor-A gene with high-altitude adaptation in yak (Bos grunniens)

文献类型： 外文期刊

第一作者： Wu, X. Y.

作者： Wu, X. Y.;Liang, C. N.;Ding, X. Z.;Guo, X.;Bao, P. J.;Chu, M.;Liu, W. B.;Yan, P.;Wu, X. Y.;Liang, C. N.;Ding, X. Z.;Guo, X.;Bao, P. J.;Chu, M.;Liu, W. B.;Yan, P.

作者机构：

关键词： Vascular endothelial growth factor A (VEGF-A);Polymorphism;High-altitude adaptation;Hypoxia adaptation;Yak

期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）

ISSN： 1676-5680

年卷期： 2013 年 12 卷 4 期

页码：

收录情况： SCI

摘要： Vascular endothelial growth factor-A gene (VEGF-A) is a key regulator of angiogenesis and an endothelial cell mitogen that plays an important role in high-altitude adaptation. In this study, we detected 2 novel single-nucleotide polymorphisms (SNPs) of VEGF-A by screening for genetic variation in 700 individuals of 3 domestic Chinese yak breeds - namely Gannan (GN), Datong (DT), and Tianzhu white (TZW) - using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing techniques. GN and DT yaks live at high altitude and TZW yaks live at low altitude on the Qinghai-Tibetan Plateau. SNP g. 8430T>C is located in intron 4 of VEGF-A. SNP g. 14853G>A is located in the 3' untranslated region of VEGF-A. Frequencies of the GA and AA genotypes and the A allele of SNP g. 14853G>A observed in GN and DT yaks were significantly higher than that in TZW yaks (P < 0.01). No significant difference among the breeds was observed for SNP g. 8430T>C. The frequency of haplotype TA was significantly higher (P < 0.01), whereas the frequency of TG (P < 0.01) was significantly lower in GN and DT yaks compared with that in TZW yaks. The 2 SNPs were in moderate linkage disequilibrium in GN and DT yaks, but not in TZW yaks. The fixation index (F-ST) pairwise value was significantly different among the breeds studied. The neutral test result indicated that the region between the 2 SNPs may have been subjected to positive or balancing selection, and the high-altitude hypoxia environment might be the main determinant for selection. These results suggest that VEGF-A might contribute to the high-altitude adaptability of yak.

分类号：

  • 相关文献

[1]Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak (Bos grunniens). Wu Xiao-yun,Ding Xue-zhi,Chu Min,Guo Xian,Bao Peng-jia,Liang Chun-nian,Yan Ping. 2015

[2]Genetic variation in the kappa-casein gene (CSN3) of Chinese yak (Bos grunniens) and phylogenetic analysis of CSN3 sequences in the genus Bos. Prinzenberg, E. -M.,Erhardt, G.,Jianlin, H.,Jianlin, H.. 2008

[3]Association between single-nucleotide polymorphisms of fatty acid synthase gene and meat quality traits in Datong Yak (Bos grunniens). Chu, M.,Wu, X. Y.,Guo, X.,Pei, J.,Liang, C. N.,Ding, X. Z.,Bao, P. J.,Yan, P.,Chu, M.,Wu, X. Y.,Guo, X.,Pei, J.,Liang, C. N.,Ding, X. Z.,Bao, P. J.,Yan, P.,Jiao, F.,Fang, H. T.. 2015

[4]Conserved Exon 2 but a Highly Polymorphic 5 '-UTR of Tyrosinase Gene in Tianzhu White Yak (Bos grunniens). Zhang, H.,Han, J. L.,Zhang, H.,Luo, Y. Z.,An, T. W.,He, J. W.,Han, J. L.. 2012

[5]Genetic polymorphisms of the IGF-II gene intron 8 coding region and its association with growth and carcass traits in yak. Zeng, Y. F.,Yu, S. J.,Zeng, Y. F.,Ding, X. Z.,Cheng, S. R.. 2013

[6]A novel single nucleotide polymorphism in exon 7 of LPL gene and its association with carcass traits and visceral fat deposition in yak (Bos grunniens) steers. Ding, X. Z.,Liang, C. N.,Guo, X.,Xing, C. F.,Bao, P. J.,Chu, M.,Pei, J.,Zhu, X. S.,Yan, P.. 2012

[7]Effects of high pressure treatment and temperature on lipid oxidation and fatty acid composition of yak (Poephagus grunniens) body fat. Wang, Qiang,Zhao, Xin,Ren, Yanrong,Wang, Qiang,Chang, Haijun,Wu, Hongbin,Fan, Enguo. 2013

[8]The Breed and Sex Effect on the Carcass Size Performance and Meat Quality of Yak in Different Muscles. Zhang, Li,Yu, Qunli,Wang, Li,Zhou, Yuchun,Li, Yongpeng,Sun, Baozhong,Xie, Peng,Li, Haipeng,Huang, Caixia,Liu, Xuan,Ji, Qiumei. 2016

[9]Effect of urea multinutritional molasses block supplementation on liveweight change of yak calves and productive and reproductive performances of yak cows. Dong, SK,Long, RJ,Kang, MY,Pu, XP,Guo, YJ. 2003

[10]Seroprevalence and Risk Factors of Fascioliasis in Yaks, Bos grunniens, from Three Counties of Gansu Province, China. Zhang, Xiao-Xuan,Ma, Jian-Gang,Zheng, Wen-Bin,Zhao, Quan,Zhang, Xiao-Xuan,Feng, Sheng-Yong,Ma, Jian-Gang,Zheng, Wen-Bin,Yin, Ming-Yang,Qin, Si-Yuan,Zhou, Dong-Hui,Zhu, Xing-Quan. 2017

[11]Foot-and-mouth disease virus carrier status in Bos grunniens yaks. Chang, Huiyun,Ma, Yanbin,Lin, Tong,Cong, Guozheng,Du, Junzheng,Ma, Jinling. 2013

[12]Molecular and serological evidence for Anaplasma infection in yaks. Ma, Miling,Liu, Zhijie,Guan, Guiquan,Li, Youquan,Luo, Jianxun,Yin, Hong.

[13]Comparative Proteomic Analysis of Yak Follicular Fluid during Estrus. Guo, Xian,Pei, Jie,Ding, Xuezhi,Chu, Min,Bao, Pengjia,Wu, Xiaoyun,Liang, Chunnian,Yan, Ping.

[14]PPAR alpha signal pathway gene expression is associated with fatty acid content in yak and cattle longissimus dorsi muscle. Qin, W.,Liang, C. N.,Guo, X.,Chu, M.,Pei, J.,Bao, P. J.,Wu, X. Y.,Li, T. K.,Yan, P.. 2015

[15]Molecular investigation of bovine viral diarrhea virus infection in yaks (Bos gruniens) from Qinghai, China. Gong, Xiaowei,Zheng, Fuying,Chen, Qiwei,Li, Zhaocai,Cao, Xiaoan,Yin, Hong,Zhou, Jizhang,Cai, Xuepeng. 2014

[16]Efficiency of in vitro embryo production of yak (Bos grunniens) cultured in different maturation and culture conditions. Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping,Guo, Xian,Ding, Xuezhi,Pei, Jie,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping. 2012

[17]Comparative proteomics of milk fat globule membrane in different species reveals variations in lactation and nutrition. Lu, Jing,Zhang, Weiqing,Liu, Lu,Pang, Xiaoyang,Zhang, Shuwen,Lv, Jiaping,Wang, Xinyu,Wang, Xinyu.

[18]Expression profiles of growth hormone receptor and insulin-like growth factor I in cattle and yak tissues revealed by quantitative real-time PCR. Pei, Jie,Lang, Xia,Guo, Xian,Bao, Pengjia,Liang, Chunnian,Chu, Min,Feng, Ruilin,Yan, Ping,Pei, Jie,Lang, Xia,Guo, Xian,Bao, Pengjia,Liang, Chunnian,Chu, Min,Yan, Ping. 2013

[19]Haemaphysalis qinghaiensis ticks transmit at least two different Theileria species: one is infective to yaks, one is infective to sheep. Yin, H,Guan, GQ,Ma, ML,Luo, JX,Lu, BY,Yuan, GL,Bai, Q,Lu, CP,Yuan, ZP,Preston, P. 2002

[20]Serological survey of Toxoplasma gondii in Tibetan mastiffs (Canis lupus familiaris) and yaks (Bos grunniens) in Qinghai, China. Wang, Meng,Wang, Yan-hua,Ye, Qiang,Meng, Peng,Yin, Hong,Zhang, De-lin. 2012

作者其他论文 更多>>

微信小程序